体力活动对多发性硬化症患者疲劳症状的影响：系统评价和荟萃分析。
The impact of physical exercise on the fatigue symptoms in patients with multiple sclerosis: a systematic review and meta-analysis.
机构信息
Department of Neurology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
BMC Neurol. 2020 Mar 13;20(1):93. doi: 10.1186/s12883-020-01654-y.
BACKGROUND
Despite many benefits of the physical activity on physical and mental health of patients with Multiple Sclerosis (MS), the activity level in these patients is still very limited, and they continue to suffer from impairment in functioning ability. The main aim of this study is thus to closely examine exercise's effect on fatigue of patients with MS worldwide, with particular interest on Iran based on a comprehensive systematic review and meta-analysis.
METHODS
The studies used in this systematic review were selected from the articles published from 1996 to 2019, in national and international databases including SID, Magiran, Iranmedex, Irandoc, Google Scholar, Cochrane, Embase, ScienceDirect, Scopus, PubMed and Web of Science (ISI). These databases were thoroughly searched, and the relevant ones were selected based on some plausible keywords to the aim of this study. Heterogeneity index between studies was determined using Cochran's test and I. Due to heterogeneity in studies, the random effects model was used to estimate standardized mean difference.
RESULTS
From the systematic review, a meta-analysis was performed on 31 articles which were fulfilled the inclusion criteria. The sample including of 714 subjects was selected from the intervention group, and almost the same sample size of 720 individuals were selected in the control group. Based on the results derived from this meta-analysis, the standardized mean difference between the intervention group before and after the intervention was respectively estimated to be 23.8 ± 6.2 and 16.9 ± 3.2, which indicates that the physical exercise reduces fatigue in patients with MS.
CONCLUSION
The results of this study extracted from a detailed meta-analysis reveal and confirm that physical exercise significantly reduces fatigue in patients with MS. As a results, a regular exercise program is strongly recommended to be part of a rehabilitation program for these patients.
背景
尽管身体活动对多发性硬化症（MS）患者的身心健康有许多益处，但这些患者的活动水平仍然非常有限，他们仍然存在功能能力受损的问题。因此，这项研究的主要目的是通过全面的系统评价和荟萃分析，密切研究运动对全球多发性硬化症患者疲劳的影响，特别是对伊朗的研究。
方法
本系统评价中使用的研究从 1996 年至 2019 年发表的文章中选取，包括国家和国际数据库，如 SID、Magiran、Irandoc、Iranmedex、Google Scholar、Cochrane、Embase、ScienceDirect、Scopus、PubMed 和 Web of Science（ISI）。这些数据库被彻底搜索，根据一些与本研究目的相关的合理关键词选择相关的数据库。使用 Cochran 检验和 I 检验来确定研究之间的异质性指数。由于研究之间存在异质性，因此使用随机效应模型来估计标准化均数差。
结果
从系统评价中，对符合纳入标准的 31 篇文章进行了荟萃分析。该样本包括干预组的 714 名受试者，对照组的样本量几乎相同，为 720 人。根据荟萃分析得出的结果，干预组干预前后的标准化均数差分别估计为 23.8±6.2 和 16.9±3.2，这表明体育锻炼可减轻多发性硬化症患者的疲劳。
结论
从详细的荟萃分析中提取的本研究结果表明并证实，体育锻炼可显著减轻多发性硬化症患者的疲劳。因此，强烈建议将定期锻炼计划作为这些患者康复计划的一部分。
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