Neurology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
CNS Oncol. 2023 Jun 1;12(2):CNS96. doi: 10.2217/cns-2022-0017. Epub 2023 Apr 24.
Glioblastoma (GBM) is the most common malignant brain tumor. Less than 1% of patients survive longer than 10 years. A 77-year-old woman was diagnosed with MGMT-methylated GBM in 2009. The patient received cilengitide as part of the CENTRIC clinical trial in conjunction with standard radiation and chemotherapy. Though the study was halted in 2013, our patient received cilengitide until 2016 with no radiographic evidence of recurrence thus far. This is the oldest reported GBM patient with greater than 10-year survival. Her exceptional response may have been influenced by MGMT promoter methylation status and PTEN expression.
胶质母细胞瘤（GBM）是最常见的恶性脑肿瘤。不到 1%的患者能存活 10 年以上。一位 77 岁的女性于 2009 年被诊断为 MGMT 甲基化的 GBM。该患者接受了西利替尼治疗，作为 CENTRIC 临床试验的一部分，与标准放疗和化疗联合使用。尽管该研究于 2013 年停止，但我们的患者一直接受西利替尼治疗，直到 2016 年，迄今为止没有影像学证据显示复发。这是目前报道的存活时间超过 10 年的最年长的 GBM 患者。她的异常反应可能受到 MGMT 启动子甲基化状态和 PTEN 表达的影响。
