Infectious Diseases Department (DIP 1) - Hospital Federal dos Servidores do Estado.
Laboratory of Clinical Research in Neuroinfections- Evandro Chagas National Institute of Infectious Diseases (INI) - FIOCRUZ.
Curr Opin Infect Dis. 2023 Jun 1;36(3):192-197. doi: 10.1097/QCO.0000000000000920. Epub 2023 Apr 6.
Brucellosis is one of the most common zoonosis worldwide, affecting 500 000 people, annually. Neurobrucellosis incidence is approximately 4%, and it is almost always heterogeneous. As there are no typical clinical features, its diagnosis is frequently misdiagnosing by other infections.
Neurobrucellosis picture includes meningitis, meningoencephalitis, encephalitis, cranial neuropathies, intracranial hypertension, sinus thrombosis, hemorrhages radiculitis, peripheral neuropathy, myelitis, and psychiatric manifestations. The diagnosis should be based on symptoms and signs suggestive of neurobrucellosis, not explained by other neurological disease, cerebrospinal fluid analysis, a positive Brucella serology or culture, and a response to specific antibiotics, with a significant improvement of cerebrospinal fluid parameters.
Neurobrucellosis can be insidious, and despite its global distribution, it is still unrecognized and frequently goes unreported. The understanding of the current epidemiology is necessary for eradication of the disease in humans, as well as the disease control in animals and prevention based on occupational hygiene and food hygiene.
布鲁氏菌病是世界范围内最常见的动物源性传染病之一，每年影响 50 万人。神经布鲁氏菌病的发病率约为 4%，且几乎总是呈异质性。由于缺乏典型的临床特征，其诊断经常被误诊为其他感染。
神经布鲁氏菌病的表现包括脑膜炎、脑膜脑炎、脑炎、颅神经病变、颅内压增高、窦血栓形成、出血性神经根炎、周围神经病、脊髓炎和精神表现。诊断应基于有神经布鲁氏菌病症状和体征，而不是由其他神经疾病引起的，脑脊液分析、布鲁氏菌血清学或培养阳性以及对特定抗生素的反应，同时脑脊液参数有明显改善。
神经布鲁氏菌病可能是隐匿的，尽管它在全球范围内分布，但仍未被认识，也经常未被报告。了解当前的流行病学情况对于在人类中消除该疾病以及控制动物疾病以及基于职业卫生和食品卫生的预防措施是必要的。
