VA Research Scientist, Boise VA Medical Center and Biomolecular Sciences Graduate Program at Boise State University.
Clinical Professor of Medicine, Division of Infectious Diseases, Department of Medicine, Loyola University Medical Center, Staff Physician and Research Scientist, Infectious Diseases Section, Edward Hines, Jr. VA Hospital, USA.
Curr Opin Infect Dis. 2023 Jun 1;36(3):164-170. doi: 10.1097/QCO.0000000000000919. Epub 2023 Apr 6.
An overview of epidemic, human adenovirus (HAdV) lung infections with proposed studies of the viral/host immune response interface to better understand mechanisms of immunopathogenesis, for development of improved responses to a potential HAdV pandemic.
Emergent HAdV strains 7, 3, 4, 14 are the most common types associated with infection outbreaks. Recent outbreaks have revealed increased community spread, beyond epidemic group settings. The ongoing circulation of these virulent HAdV strains might allow for further HAdV adaptation, with increased HAdV spread and disease severity in the population that could theoretically result in expansion to a pandemic level.
Public health screening has revealed spread of HAdV outbreak strains to the general community. Despite expanded awareness of viral respiratory diseases during the SARS-CoV-2 pandemic, there has been limited, systematic monitoring of HAdV infection in the population. The shift in clinical laboratories to a focus on molecular diagnostics and away from classical methods of viral characterization has reduced the distribution of outbreak HAdV strains to the research community to study mechanisms of pathogenesis. This change risks reduced development of new preventive and therapeutic strategies that could be needed in the event of more widespread HAdV epidemics.
综述目的：概述人类腺病毒（HAdV）肺部感染的流行情况，探讨病毒/宿主免疫反应界面的研究，以更好地了解免疫发病机制的机制，为潜在的 HAdV 大流行开发改进的应对措施。
最新发现：新兴的 HAdV 7、3、4、14 株是与感染爆发相关的最常见类型。最近的爆发表明，社区传播的范围已经超出了流行群体。这些高毒力 HAdV 株的持续循环可能允许进一步的 HAdV 适应，导致人群中 HAdV 的传播和疾病严重程度增加，理论上可能导致疫情扩大到大流行水平。
总结：公共卫生筛查显示，HAdV 爆发株已传播到普通社区。尽管在 SARS-CoV-2 大流行期间对病毒性呼吸道疾病的认识有所扩大，但对人群中 HAdV 感染的系统监测有限。临床实验室向分子诊断的转变，以及远离病毒特征的经典方法，减少了爆发 HAdV 株在研究社区中的分布，以研究发病机制的机制。这种变化可能会减少新的预防和治疗策略的开发，而这些策略在更广泛的 HAdV 流行时可能是必要的。
