Ramakrishna B S, Mathan V I
Dig Dis Sci. 1987 May;32(5):500-5. doi: 10.1007/BF01296033.
Colonic perfusion studies in 10 southern Indian patients with tropical sprue and nine matched healthy adults revealed a defect of water and sodium absorption from the colon in sprue. Heat-labile and heat-stable enterotoxin production was not detected in coliforms cultured from the feces of any of the 19 subjects. The 24-hr fecal bile acid output was increased in patients with sprue, but fecal aqueous bile acid concentrations remained within normal limits, and these did not correlate with defects in colonic water and sodium absorption. Fecal free fatty acid excretion was markedly increased in sprue. There was a negative correlation between fecal excretion of unsaturated free fatty acids and colonic water and sodium absorption.
对10名患有热带口炎性腹泻的印度南部患者和9名匹配的健康成年人进行的结肠灌注研究显示，口炎性腹泻患者存在结肠水和钠吸收缺陷。在这19名受试者的粪便中培养出的大肠菌中未检测到不耐热和耐热肠毒素的产生。口炎性腹泻患者的24小时粪便胆汁酸排出量增加，但粪便中水性胆汁酸浓度仍在正常范围内，且这些浓度与结肠水和钠吸收缺陷无关。口炎性腹泻患者粪便中游离脂肪酸排泄显著增加。不饱和游离脂肪酸的粪便排泄与结肠水和钠吸收之间呈负相关。
