磁共振胆系造影中钆对比剂在盐水、血液和胆汁中的比较：一项仿体研究。
Comparison of gadolinium-based contrast agents for MR cholangiography in saline, blood and bile: a phantom study.
机构信息
Clinical Research Group, Klus Apotheke Zurich, Zurich, Switzerland.
Faculté de Pharmacie, Université de Montréal, 2940 Chemin de Polytechnique, Montreal, QC, H3T 1J4, Canada.
出版信息
Eur Radiol Exp. 2023 Apr 24;7(1):21. doi: 10.1186/s41747-023-00331-2.
BACKGROUND
We compared T1- and T2-weighted signal intensities of liver-specific (gadoxetate, gadobenate) and non-specific (gadoterate) gadolinium contrast agents (CAs) in a bile phantom.
METHODS
In a phantom study, gadoxetate, gadobenate, and gadoterate were diluted in saline, blood, and bile at different concentrations (0, 0.25, 0.5. 1, 2.5, 5, 10, and 25 mM) and imaged in a 3-T magnetic resonance imaging (MRI) system using T1- and T2-weighted sequences. The maximum signal intensities of CAs were compared for each sequence separately and across all T1-weighted sequences using one-way ANOVA.
RESULTS
Using T1-weighted sequences, CA concentration-dependent signal intensity increase was followed by decrease due to T2* effects. Comparing CAs for each sequence in bile yielded higher maximum signal intensities with gadobenate than gadoxetate and gadoterate using T1-weighted spin-echo (p < 0.010), multiecho gradient- and spin-echo (p < 0.001), and T1-weighted high-resolution isotropic volume excitation (eTHRIVE) sequences (p < 0.010). Comparing across all T1-weighted sequences in the bile phantom, gadobenate imaged using T1-weighted turbo field-echo (TFE) sequence showed the highest signal intensity, significantly higher than that using other CAs agents or sequences (p < 0.004) except for gadobenate and gadoxetate evaluated with three-dimensional multiecho fast field-echo (3D-mFFE) and gadoxetate with T1-weighted TFE sequence (p > 0.141). Signal reduction with CA concentration-dependent decrease was observed on T2-weighted images.
CONCLUSION
In this bile phantom study of gadolinium-based CA, gadobenate and gadoxetate showed high signal intensity with T1-weighted TFE and 3D-mFFE sequences, which supports their potential utility for contrast-enhanced hepatobiliary MRI.
KEY POINTS
• Contrast-enhanced magnetic resonance (MR) cholangiography depends on contrast agent type, kinetics, and concentration in bile, • We compared signal intensities of three contrast agents in a bile phantom study. • Gadobenate, gadoxetate, and gadoterate demonstrated different signal intensities at identical concentrations. • Gadoxetate and gadobenate showed high signal intensities on T1-weighted MR sequences.
背景
我们比较了肝特异性（钆塞酸，钆贝酸）和非特异性（钆特酸）钆对比剂（CA）在胆汁模型中的 T1 和 T2 加权信号强度。
方法
在一项模型研究中，将钆塞酸、钆贝酸和钆特酸分别在盐水、血液和胆汁中稀释至不同浓度（0、0.25、0.5、1、2.5、5、10 和 25 mM），并在 3-T 磁共振成像（MRI）系统中使用 T1 和 T2 加权序列进行成像。分别比较了每个序列的 CA 最大信号强度，并使用单向方差分析比较了所有 T1 加权序列的信号强度。
结果
使用 T1 加权序列，由于 T2*效应，CA 浓度依赖性信号强度增加后会下降。在胆汁中比较每个序列的 CA，使用 T1 加权自旋回波（SE）序列，钆贝酸的最大信号强度高于钆塞酸和钆特酸（p<0.010），多回波梯度和自旋回波（p<0.001），以及 T1 加权高分辨率各向同性容积激发（eTHRIVE）序列（p<0.010）。在胆汁模型中比较所有 T1 加权序列，使用 T1 加权涡轮场回波（TFE）序列成像的钆贝酸显示出最高的信号强度，明显高于其他 CA 制剂或序列（p<0.004），除了钆贝酸和钆塞酸使用三维多回波快速场回波（3D-mFFE）评估（p>0.141）和钆塞酸使用 T1 加权 TFE 序列（p>0.141）。在 T2 加权图像上观察到 CA 浓度依赖性降低导致的信号减少。
结论
在这项关于基于钆的 CA 的胆汁模型研究中，钆贝酸和钆塞酸在 T1 加权 TFE 和 3D-mFFE 序列中显示出高信号强度，这支持它们在对比增强肝胆磁共振成像中的潜在应用。
重点
对比增强磁共振（MR）胆管成像取决于胆汁中的对比剂类型、动力学和浓度。
我们在一项胆汁模型研究中比较了三种对比剂的信号强度。
钆贝酸、钆塞酸和钆特酸在相同浓度下显示出不同的信号强度。
钆塞酸和钆贝酸在 T1 加权磁共振序列上显示出高信号强度。
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