Lobo J, Jack D B, Kendall M J
Eur J Clin Pharmacol. 1986;30(1):57-60. doi: 10.1007/BF00614196.
Plasma concentrations of Nifedipine were measured following single oral doses of Nifedipine Slow Release (Adalat Retard) on three separate occasions to young, healthy volunteers of both sexes. Intra- and inter-subject variability were assessed by comparing the pharmacokinetic parameters, AUC, Cmax and T50%AUC. Interindividual variability was less than that observed in other studies with the beta-blockers, metoprolol and propranolol and there was no evidence of differences between the sexes.
在三个不同时间点，对年轻健康的男女志愿者单次口服硝苯地平缓释片（拜新同缓释片）后测定血浆硝苯地平浓度。通过比较药代动力学参数AUC、Cmax和T50%AUC评估受试者内和受试者间的变异性。个体间变异性小于在其他使用β受体阻滞剂美托洛尔和普萘洛尔的研究中观察到的变异性，且没有证据表明性别之间存在差异。
