骨保护素的预后作用与冠状动脉钙化风险：一项系统评价和荟萃分析
Prognostic role of osteoprotegerin and risk of coronary artery calcification: a systematic review and meta-analysis.
作者信息
Samadi Sara, Sadeghi Masoumeh, Dashtbayaz Reza Javidi, Nezamdoost Shirin, Mohammadpour Amir H, Jomehzadeh Vahid
机构信息
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 91775-1365, Iran.
Department of Epidemiology, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, 91775-1365, Iran.
出版信息
Biomark Med. 2023 Feb;17(3):171-180. doi: 10.2217/bmm-2022-0621. Epub 2023 Apr 25.
Coronary artery calcification (CAC) is a predictor of atherosclerosis. However, the association of osteoprotegerin (OPG) with CAC is still controversial. Prospective cohort studies that provided odds ratios with 95% CIs were included from PubMed, Embase, Web of Science and Scopus through July 2022. Out of 14 studies included in the systematic review, three studies with 7642 participants were included in the meta-analysis. The pooled odds ratio indicated a significant association between higher OPG levels and accelerated risk of CAC (1.15; 95% CI: 1.03-1.30; p < 0.001) with relatively no heterogeneity between studies (I = 0%; p = 0.43). The results indicated that increased concentrations of OPG are positively associated with a 15% elevated odds of CAC after adjustment of major covariates.
冠状动脉钙化（CAC）是动脉粥样硬化的一个预测指标。然而，骨保护素（OPG）与CAC之间的关联仍存在争议。通过检索PubMed、Embase、Web of Science和Scopus数据库，纳入截至2022年7月提供比值比及95%置信区间的前瞻性队列研究。在系统评价纳入的14项研究中，有3项研究（共7642名参与者）被纳入荟萃分析。汇总比值比表明，较高的OPG水平与CAC风险加速显著相关（1.15；95%置信区间：1.03 - 1.30；p < 0.001），各研究间异质性相对较小（I = 0%；p = 0.43）。结果表明，在调整主要协变量后，OPG浓度升高与CAC发生几率升高15%呈正相关。
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