ctDNA 监测在小细胞肺癌中的应用：是否已准备好成为主流？
ctDNA Monitoring for Small Cell Lung Cancer: Ready for Prime Time?
机构信息
Department of Thoracic Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida.
Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida.
出版信息
Clin Cancer Res. 2023 Jun 13;29(12):2176-2178. doi: 10.1158/1078-0432.CCR-23-0420.
Abstract
Small cell lung cancer (SCLC) is the deadliest form of lung cancer and has few precision medicine approaches available. A recent study analyzed circulating tumor DNA (ctDNA) in 33 patients with extensive-stage SCLC and showed that ctDNA levels and response patterns correlate strongly with clinical response and survival outcomes. See related article by Sivapalan et al., p. 2310.
摘要
小细胞肺癌（SCLC）是肺癌中最致命的形式，可用的精准医疗方法很少。最近的一项研究分析了 33 例广泛期 SCLC 患者的循环肿瘤 DNA（ctDNA），结果表明 ctDNA 水平和反应模式与临床反应和生存结果密切相关。见 Sivapalan 等人的相关文章，第 2310 页。
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本文引用的文献
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Clin Cancer Res. 2023 Jun 13;29(12):2310-2323. doi: 10.1158/1078-0432.CCR-22-2242.
2
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White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer.胃癌残留病灶检测的白细胞和游离 DNA 分析。
Nat Commun. 2020 Jan 27;11(1):525. doi: 10.1038/s41467-020-14310-3.
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COSMIC: the Catalogue Of Somatic Mutations In Cancer.COSMIC：癌症体细胞突变目录。
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Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer.循环肿瘤 DNA 分析描绘了小细胞肺癌的亚克隆结构和基因组进化。
Nat Commun. 2018 Aug 6;9(1):3114. doi: 10.1038/s41467-018-05327-w.
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Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse.纵向分析小细胞肺癌患者的游离 DNA 可深入了解治疗效果和疾病复发的动态。
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