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SLE 不是一种一刀切的疾病。

SLE is not a one-size-fits-all disease.

机构信息

Department of Rheumatology, University College London , London, UK.

出版信息

J Exp Med. 2023 Jun 5;220(6). doi: 10.1084/jem.20230559. Epub 2023 Apr 25.

DOI:10.1084/jem.20230559
PMID:37097613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10130747/
Abstract

In this Viewpoint we discuss how experimental medicine applied in the setting of clinical trials can address unmet need in the prototypic autoimmune disease systemic lupus erythematosus (SLE) to improve outcomes for patients.

摘要

在本观点文章中,我们探讨了在临床试验背景下应用的实验医学如何能够满足典型自身免疫性疾病系统性红斑狼疮(SLE)未满足的需求,从而改善患者的预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f50a/10130747/07426775d1e2/JEM_20230559_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f50a/10130747/07426775d1e2/JEM_20230559_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f50a/10130747/07426775d1e2/JEM_20230559_Fig1.jpg

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本文引用的文献

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Non-coding RNAs: Key players in T cell exhaustion.非编码 RNA:T 细胞耗竭的关键因素。
Front Immunol. 2022 Oct 4;13:959729. doi: 10.3389/fimmu.2022.959729. eCollection 2022.
2
Immunosuppressant exposure confounds gene expression analysis in systemic lupus erythematosus.免疫抑制剂的使用会干扰系统性红斑狼疮的基因表达分析。
Front Immunol. 2022 Aug 17;13:964263. doi: 10.3389/fimmu.2022.964263. eCollection 2022.
3
Deconvoluting the heterogeneity of SLE: The contribution of ancestry.解析 SLE 的异质性:遗传背景的作用。
J Allergy Clin Immunol. 2022 Jan;149(1):12-23. doi: 10.1016/j.jaci.2021.11.005. Epub 2021 Nov 29.
4
Anifrolumab in Systemic Lupus Erythematosus. Reply.阿尼鲁单抗治疗系统性红斑狼疮。回复。
N Engl J Med. 2020 Apr 23;382(17):1666. doi: 10.1056/NEJMc2002191.
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String of successful trials in SLE: have we cracked the code?系统性红斑狼疮(SLE)一系列成功的试验:我们破解其中的奥秘了吗?
Lupus Sci Med. 2020 Jan 2;7(1):e000380. doi: 10.1136/lupus-2019-000380. eCollection 2020.
6
Machine learning applied to whole-blood RNA-sequencing data uncovers distinct subsets of patients with systemic lupus erythematosus.应用于全血RNA测序数据的机器学习揭示了系统性红斑狼疮患者的不同亚组。
Clin Transl Immunology. 2019 Dec 12;8(12):e01093. doi: 10.1002/cti2.1093. eCollection 2019.
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Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity.系统性红斑狼疮患者的联合遗传和转录组分析:易感性和严重程度的独特、可靶向特征。
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Brief Report: Lupus-An Unrecognized Leading Cause of Death in Young Females: A Population-Based Study Using Nationwide Death Certificates, 2000-2015.简要报告:狼疮——年轻女性中未被识别的主要死因:2000-2015 年基于全国死亡证明的人群研究。
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