State Key Laboratory of Trauma, Burns, and Combined Injury, Department of Shock and Transfusion, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 400042, China.
New Beta Innovation Limited, Kowloon Bay, Hong Kong, Hong Kong SAR, 999077, China.
Adv Biol (Weinh). 2023 Aug;7(8):e2200307. doi: 10.1002/adbi.202200307. Epub 2023 Apr 25.
The prevalence and severity of high-altitude sickness increases with increasing altitude. Prevention of hypoxia caused by high-altitude sickness is an urgent problem. As a novel oxygen-carrying fluid, modified hemoglobin can carry oxygen in a full oxygen partial pressure environment and release oxygen in a low oxygen partial pressure environment. It is unclear whether modified hemoglobin can improve hypoxic injury on a plateau. Using hypobaric chamber rabbit (5000 m) and plateau goat (3600 m) models, general behavioral scores and vital signs, hemodynamic, vital organ functions, and blood gas are measured. The results show that the general behavioral scores and vital signs decrease significantly in the hypobaric chamber or plateau, and the modified hemoglobin can effectively improve the general behavioral scores and vital signs in rabbits and goats, and reduce the degree of damage to vital organs. Further studies reveal that arterial partial pressure of oxygen (PaO ) and arterial oxygen saturation (SaO ) on the plateau decrease rapidly, and the modified hemoglobin could increase PaO and SaO ; thus, increasing the oxygen-carrying capacity. Moreover, modified hemoglobin has few side effects on hemodynamics and kidney injury. These results indicate that modified hemoglobin has a protective effect against high-altitude sickness.
高原病的患病率和严重程度随海拔升高而增加。预防高原病引起的缺氧是一个紧迫的问题。作为一种新型携氧液，改性血红蛋白可以在全氧分压环境中携带氧，并在低氧分压环境中释放氧。目前尚不清楚改性血红蛋白是否可以改善高原缺氧损伤。使用低压舱兔（5000 米）和平原山羊（3600 米）模型，测量一般行为评分和生命体征、血流动力学、重要器官功能和血气。结果表明，低压舱或高原时一般行为评分和生命体征显著下降，改性血红蛋白能有效改善兔和山羊的一般行为评分和生命体征，降低重要器官损伤程度。进一步研究表明，高原时动脉血氧分压（PaO ）和动脉血氧饱和度（SaO ）迅速下降，改性血红蛋白可增加 PaO 和 SaO ；从而增加携氧能力。此外，改性血红蛋白对血液动力学和肾损伤的副作用较小。这些结果表明，改性血红蛋白对高原病具有保护作用。
