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在 Cyberknife 前列腺 SBRT 治疗中使用细导丝进行尿道定义。

The use of a thin guide-wire for urethral definition in prostate SBRT treatments with Cyberknife.

机构信息

Medical Physics Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.

Radiation Oncology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.

出版信息

J Appl Clin Med Phys. 2023 Aug;24(8):e14006. doi: 10.1002/acm2.14006. Epub 2023 Apr 25.

DOI:10.1002/acm2.14006
PMID:37097754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10402662/
Abstract

PURPOSE

To study and analyze the effect of the use of a thin guide-wire instead of a Foley catheter for urethral definition in prostate stereotactic body radiation therapy (SBRT) treatments and to compare treatment parameters in both situations.

MATERIAL AND METHODS

Thirty-seven prostate SBRT patients were employed in this study. A Foley catheter was employed in nine of them, and a guide-wire was employed in the other 28 patients. For each of the 28 patients in which the guide-wire was employed, a comparison between urethral positions in both situations was performed, allowing for a margin definition of the urethra when a Foley catheter was employed. Displacements of the prostate during treatment were obtained, allowing for an analysis of prostate positions in both situations. Also, different treatment parameters such as the number of treatment interruptions, couch movements performed, and x-rays needed were gathered.

RESULTS

Large differences between urethral positions can be found in the anterior-posterior (AP) directions compared to those in the lateral (LAT) direction. Differences are also larger in areas closer to the base of the prostate, where margins applied in the case of using a Foley catheter are 16 mm with a mean displacement of 6 mm in the posterior direction. No differences in the treatment parameters were found during treatment in both situations. The difference found in absolute prostate pitch rotations suggests that the Foley catheter provokes a shift of the prostate position, which does not occur when employing the guide-wire.

CONCLUSIONS

Foley catheters shift the urethral position, making them a wrong surrogate of the urethra when no catheters are present. The margins needed to assess uncertainties introduced by the use of a Foley catheter are larger than those usually applied. The use of a Foley catheter did not present any additional difficulty during treatment delivery in terms of images employed or interruptions produced.

摘要

目的

研究和分析在前列腺立体定向体部放射治疗(SBRT)中使用细导丝代替 Foley 导管进行尿道定义的效果,并比较两种情况下的治疗参数。

材料和方法

本研究纳入了 37 例前列腺 SBRT 患者。其中 9 例使用 Foley 导管,28 例使用导丝。对于使用导丝的 28 例患者中的每例患者,比较了两种情况下的尿道位置,以便在使用 Foley 导管时定义尿道的边缘。获得了前列腺在治疗过程中的位移,从而可以分析两种情况下的前列腺位置。此外,还收集了不同的治疗参数,如治疗中断次数、治疗床移动次数和所需的 X 射线数量。

结果

与侧向(LAT)方向相比,前-后(AP)方向的尿道位置差异较大。靠近前列腺基部的区域差异更大,在该区域使用 Foley 导管时的边缘为 16mm,后向平均位移为 6mm。两种情况下的治疗参数在治疗过程中无差异。绝对前列腺旋转角度的差异表明,Foley 导管会引起前列腺位置的移位,而使用导丝时则不会。

结论

Foley 导管会改变尿道位置,使其成为没有导管时尿道的错误替代物。为评估使用 Foley 导管引起的不确定性而需要的边缘大于通常应用的边缘。就使用的图像或产生的中断而言,在治疗过程中使用 Foley 导管并没有带来任何额外的困难。

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本文引用的文献

1
Urethral and bladder dose-effect relations for late genitourinary toxicity following external beam radiotherapy for prostate cancer in the FLAME trial.在 FLAME 试验中,外照射放疗治疗前列腺癌后晚期泌尿生殖系统毒性的尿道和膀胱剂量-效应关系。
Radiother Oncol. 2022 Feb;167:127-132. doi: 10.1016/j.radonc.2021.12.027. Epub 2021 Dec 28.
2
Radiation Dose to the Intraprostatic Urethra Correlates Strongly With Urinary Toxicity After Prostate Stereotactic Body Radiation Therapy: A Combined Analysis of 23 Prospective Clinical Trials.前列腺立体定向体部放射治疗后,前列腺内尿道的辐射剂量与尿毒性密切相关:23 项前瞻性临床试验的联合分析。
Int J Radiat Oncol Biol Phys. 2022 Jan 1;112(1):75-82. doi: 10.1016/j.ijrobp.2021.06.037. Epub 2021 Oct 25.
3
Visualizing the urethra by magnetic resonance imaging without usage of a catheter for radiotherapy of prostate cancer.在不使用导管的情况下通过磁共振成像可视化尿道以用于前列腺癌放疗。
Phys Imaging Radiat Oncol. 2021 Mar 26;18:1-4. doi: 10.1016/j.phro.2021.03.002. eCollection 2021 Apr.
4
Focal Boost to the Intraprostatic Tumor in External Beam Radiotherapy for Patients With Localized Prostate Cancer: Results From the FLAME Randomized Phase III Trial.局部前列腺癌外照射放疗中前列腺内肿瘤焦点增强:来自 FLAME 随机 III 期试验的结果。
J Clin Oncol. 2021 Mar 1;39(7):787-796. doi: 10.1200/JCO.20.02873. Epub 2021 Jan 20.
5
The urethral position may shift due to urethral catheter placement in the treatment planning for prostate radiation therapy.在前列腺放射治疗的治疗计划中,由于尿道置管,尿道位置可能会发生移位。
Radiat Oncol. 2019 Dec 12;14(1):226. doi: 10.1186/s13014-019-1424-8.
6
Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial.强度调制分割放疗与立体定向体部放疗治疗前列腺癌(PACE-B):一项国际、随机、开放标签、3 期、非劣效性试验的急性毒性研究结果。
Lancet Oncol. 2019 Nov;20(11):1531-1543. doi: 10.1016/S1470-2045(19)30569-8. Epub 2019 Sep 17.
7
Comparison of Motion-Insensitive T2-Weighted MRI Pulse Sequences for Visualization of the Prostatic Urethra During MR Simulation.在磁共振模拟成像中,用于显示前列腺尿道的运动不敏感 T2 加权 MRI 脉冲序列的比较。
Pract Radiat Oncol. 2019 Nov;9(6):e534-e540. doi: 10.1016/j.prro.2019.06.009. Epub 2019 Jun 25.
8
Changes in prostate orientation due to removal of a Foley catheter.由于 Foley 导管的移除导致前列腺位置的改变。
Med Phys. 2018 Apr;45(4):1369-1378. doi: 10.1002/mp.12830. Epub 2018 Mar 25.
9
MRI micturating urethrography for improved urethral delineation in prostate radiotherapy planning: a case study.磁共振成像排尿尿道造影术用于改善前列腺放疗计划中尿道的描绘:一项病例研究
Phys Med Biol. 2017 Apr 21;62(8):3003-3010. doi: 10.1088/1361-6560/62/8/3003. Epub 2017 Mar 17.
10
Early results of urethral dose reduction and small safety margin in intensity-modulated radiation therapy (IMRT) for localized prostate cancer using a real-time tumor-tracking radiotherapy (RTRT) system.使用实时肿瘤追踪放疗(RTRT)系统对局限性前列腺癌进行调强放疗(IMRT)时尿道剂量降低及小安全 margins 的早期结果 。 (注:这里“safety margin”直译为“安全裕度”,在医学放疗语境中可能是指安全边界等意思,因未明确具体所指,保留英文未翻译更准确。)
Radiat Oncol. 2014 May 21;9:118. doi: 10.1186/1748-717X-9-118.