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磁共振成像排尿尿道造影术用于改善前列腺放疗计划中尿道的描绘:一项病例研究

MRI micturating urethrography for improved urethral delineation in prostate radiotherapy planning: a case study.

作者信息

Rai Robba, Sidhom Mark, Lim Karen, Ohanessian Lucy, Liney Gary P

机构信息

Liverpool and Macarthur Cancer Therapy Centres, Liverpool, Australia. Ingham Institute for Applied Medical Research, Liverpool, Australia.

出版信息

Phys Med Biol. 2017 Apr 21;62(8):3003-3010. doi: 10.1088/1361-6560/62/8/3003. Epub 2017 Mar 17.

Abstract

Stereotactic ablative body radiotherapy is used in prostate cancer to deliver a high dose of radiation to the tumour over a small number of treatments. This involves the simulation of the patient using both CT and MRI. Current practice is to insert an indwelling catheter (IDC) during CT to assist with visualisation of the urethra and subsequently minimise dose to this highly critical structure. However, this procedure is invasive and has an associated risk of infection. This is a case study, which demonstrates our initial experience of using a real-time non-invasive MRI technique to replace the use of IDC for prostate cancer patients. The patient was scanned on a dedicated 3T MRI and was instructed to micturate in their own time whereupon a sagittal T2 weighted HASTE sequence was acquired every 5 s. This was subsequently followed by T2 weighted axial imaging at the level of mid prostate to provide improved urethral definition. Acquired images showed bladder voidance in real-time and an increase in signal intensity in the proximal urethra post voiding allowing for delineation of the urethra. The dimension and shape of the proximal urethra was well visualised and accumulation time of urine in the urethra was sufficient to enable optimum timing of the scanning technique. We have presented for the first time a micturating urethography technique using MRI, which has allowed us to visualise the urethra without contrast and with minimal invasiveness to the patient.

摘要

立体定向消融体部放射治疗用于前列腺癌,通过少量治疗将高剂量辐射传递至肿瘤。这涉及使用CT和MRI对患者进行模拟。目前的做法是在CT检查期间插入留置导管(IDC),以辅助观察尿道,并随后将对这个高度关键结构的剂量降至最低。然而,该操作具有侵入性且存在感染风险。这是一项病例研究,展示了我们使用实时非侵入性MRI技术替代前列腺癌患者使用IDC的初步经验。患者在专用的3T MRI上进行扫描,并被指示在自己方便的时候排尿,随后每5秒获取一次矢状位T2加权HASTE序列。随后在前列腺中部水平进行T2加权轴位成像,以提供更好的尿道清晰度。获取的图像实时显示膀胱排空情况,排尿后近端尿道信号强度增加,从而能够勾勒出尿道。近端尿道的尺寸和形状清晰可见,尿道内尿液的积聚时间足以实现扫描技术的最佳时机。我们首次展示了一种使用MRI的排尿尿道造影技术,该技术使我们能够在不使用造影剂且对患者侵入性最小的情况下观察尿道。

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