Zverev Ia F
Farmakol Toksikol. 1986 Mar-Apr;49(2):62-3.
Dichlothiazide and butadione were shown to attenuate equally the development of the rat paw inflammatory edema induced by subplantar dextran administration. Ethacrynic acid produced more pronounced antiedematous effect. Also, ethacrynic acid reduced to the highest degree the damp and dry mass of the inflammatory granuloma. Oxadoline and butadione considerably inhibit the formation of granuloma as well. The combined use of diuretics and butadione did not lead to a mutual potentiation of the antiinflammatory effect in exudative and proliferative inflammation.
双氢氯噻嗪和丁二酮对足底注射葡聚糖诱导的大鼠爪部炎性水肿的发展具有同等程度的减轻作用。依他尼酸产生更显著的抗水肿作用。此外，依他尼酸能最大程度地减轻炎性肉芽肿的湿重和干重。奥沙多林和丁二酮也能显著抑制肉芽肿的形成。利尿剂和丁二酮联合使用在渗出性和增殖性炎症中并未导致抗炎作用的相互增强。
