Zverev Ia F, Shelemba M V, Belomestnykh V G
Farmakol Toksikol. 1985 Nov-Dec;48(6):47-8.
It is shown that ethacrynic acid and dichlothiazide in 50 mg/kg dose reduce the dextran-induced increase of rat skin vascular permeability. Besides, durable administration of furosemide, dichlothiazide and ethacrynic acid in 50-80 mg/kg doses decreases the dry mass of inflammatory granuloma. This fact shows the ability of diuretics to suppress the development of proliferative inflammation.
结果表明，50毫克/千克剂量的依他尼酸和双氢氯噻嗪可降低右旋糖酐诱导的大鼠皮肤血管通透性增加。此外，持续给予50 - 80毫克/千克剂量的速尿、双氢氯噻嗪和依他尼酸可降低炎性肉芽肿的干重。这一事实表明利尿剂具有抑制增生性炎症发展的能力。
