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人子宫冲洗液中类子宫珠蛋白抗原的鉴定。

Identification of a uteroglobin-like antigen in human uterine washings.

作者信息

Cowan B D, North D H, Whitworth N S, Fujita R, Shumacher E K, Mukherjee A B

出版信息

Fertil Steril. 1986 Jun;45(6):820-3. doi: 10.1016/s0015-0282(16)49399-4.

DOI:10.1016/s0015-0282(16)49399-4
PMID:3709830
Abstract

A uteroglobin-like molecule was detected with a sensitive radioimmunoassay for rabbit uteroglobin in the uterine washings of women. This antigen was detectable only in small amounts in the uterine washings obtained from women in the late luteal phase or proliferative phase, but was detected in large amounts in uterine washings of women collected during the early and midluteal phases of the ovarian-menstrual cycle. Our findings suggest that antigenically similar portions of rabbit uteroglobin have been phylogenetically conserved in women, and that endometrial production and secretion of this human uteroglobin-like antigen may be hormonally regulated.

摘要

采用灵敏的兔子宫珠蛋白放射免疫分析法,在女性子宫冲洗液中检测到一种类似子宫珠蛋白的分子。该抗原仅在黄体晚期或增殖期女性的子宫冲洗液中少量可检测到,但在卵巢-月经周期黄体早期和中期收集的女性子宫冲洗液中大量检测到。我们的研究结果表明,兔子宫珠蛋白的抗原相似部分在女性进化过程中得以保守,并且这种人类子宫珠蛋白样抗原的子宫内膜产生和分泌可能受激素调节。

相似文献

1
Identification of a uteroglobin-like antigen in human uterine washings.人子宫冲洗液中类子宫珠蛋白抗原的鉴定。
Fertil Steril. 1986 Jun;45(6):820-3. doi: 10.1016/s0015-0282(16)49399-4.
2
Uteroglobin-like antigens in species of Lagomorpha.兔形目动物中的子宫珠蛋白样抗原。
Comp Biochem Physiol B. 1982;71(3):511-4. doi: 10.1016/0305-0491(82)90417-5.
3
Uterine and lung uteroglobins in the rabbit. Two similar proteins with differential hormonal regulation.兔子宫和肺中的子宫珠蛋白。两种具有不同激素调节作用的相似蛋白质。
Biochim Biophys Acta. 1978 Dec 18;544(3):578-92. doi: 10.1016/0304-4165(78)90332-x.
4
Uteroglobin-like antigen in the male genital tract secretions.男性生殖道分泌物中的子宫珠蛋白样抗原。
Cell Tissue Res. 1975 Dec 29;165(1):1-11. doi: 10.1007/BF00222795.
5
Proteinase inhibitor identification in the uteroglobin fraction of rabbit uterine secretion.兔子宫分泌物子宫珠蛋白组分中的蛋白酶抑制剂鉴定
Arch Gynecol. 1982;231(4):289-97. doi: 10.1007/BF02111727.
6
Detection of a rabbit uteroglobin-like protein in human neonatal tracheobronchial washings.在人类新生儿气管支气管灌洗液中检测到一种兔子宫珠蛋白样蛋白。
Biochem Biophys Res Commun. 1988 May 16;152(3):1447-54. doi: 10.1016/s0006-291x(88)80448-0.
7
Genital tract proteins in the male rabbit: I. Localization of uteroglobin.雄性兔生殖道蛋白:I. 子宫珠蛋白的定位
Andrologia. 1983 Jul-Aug;15(4):380-4. doi: 10.1111/j.1439-0272.1983.tb00157.x.
8
Evidence of a uteroglobin-like protein in epithelial cells of reproductive and non-reproductive tissues of the rabbit.兔生殖和非生殖组织上皮细胞中类子宫珠蛋白样蛋白的证据。
J Reprod Fertil. 1978 Sep;54(1):193-6. doi: 10.1530/jrf.0.0540193.
9
Expression of a uteroglobin-like protein in human prostate.一种类子宫珠蛋白在人前列腺中的表达。
J Urol. 1988 Jul;140(1):176-82. doi: 10.1016/s0022-5347(17)41522-9.
10
Immunocytochemical localization of uteroglobin in the rabbit endometrium.子宫珠蛋白在兔子宫内膜中的免疫细胞化学定位。
Anat Embryol (Berl). 1985;172(3):295-301. doi: 10.1007/BF00318977.

引用本文的文献

1
Resonance assignment and secondary structure determination and stability of the recombinant human uteroglobin with heteronuclear multidimensional NMR.利用异核多维核磁共振技术对重组人子宫珠蛋白进行共振归属、二级结构测定及稳定性研究。
J Biomol NMR. 1997 Jan;9(1):35-46. doi: 10.1023/a:1018619501038.
2
Endometrial cultures and their application to new reproductive technologies: a look ahead.
J In Vitro Fert Embryo Transf. 1991 Jun;8(3):119-26. doi: 10.1007/BF01131700.