人子宫冲洗液中类子宫珠蛋白抗原的鉴定。

Identification of a uteroglobin-like antigen in human uterine washings.

作者信息

Cowan B D, North D H, Whitworth N S, Fujita R, Shumacher E K, Mukherjee A B

出版信息

Fertil Steril. 1986 Jun;45(6):820-3. doi: 10.1016/s0015-0282(16)49399-4.

Abstract

A uteroglobin-like molecule was detected with a sensitive radioimmunoassay for rabbit uteroglobin in the uterine washings of women. This antigen was detectable only in small amounts in the uterine washings obtained from women in the late luteal phase or proliferative phase, but was detected in large amounts in uterine washings of women collected during the early and midluteal phases of the ovarian-menstrual cycle. Our findings suggest that antigenically similar portions of rabbit uteroglobin have been phylogenetically conserved in women, and that endometrial production and secretion of this human uteroglobin-like antigen may be hormonally regulated.

摘要

采用灵敏的兔子宫珠蛋白放射免疫分析法，在女性子宫冲洗液中检测到一种类似子宫珠蛋白的分子。该抗原仅在黄体晚期或增殖期女性的子宫冲洗液中少量可检测到，但在卵巢-月经周期黄体早期和中期收集的女性子宫冲洗液中大量检测到。我们的研究结果表明，兔子宫珠蛋白的抗原相似部分在女性进化过程中得以保守，并且这种人类子宫珠蛋白样抗原的子宫内膜产生和分泌可能受激素调节。