Dhanireddy R, Kikukawa T, Mukherjee A B
Section on Developmental Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
Biochem Biophys Res Commun. 1988 May 16;152(3):1447-54. doi: 10.1016/s0006-291x(88)80448-0.
Uteroglobin is a steroid hormone dependent, low molecular weight, secretory protein with many immunomodulatory properties. Immunomodulation by this protein may, at least in part, be related to its inhibitory effects on phospholipase A2 activity. Although uteroglobin is conclusively found in the rabbit, its presence in the human is controversial. Here, we present biochemical and immunological evidence for the detection of a uteroglobin-like protein in the wet epithelial living of the respiratory tract of human neonates. Because inhibition of phospholipase A2 may modulate tissue eicosanoid levels and since many eicosanoids (i.e. prostaglandins and leukotrienes etc.) are well known regulators of smooth muscle contractility, cellular migration and inflammatory processes, the discovery of this protein in the human respiratory tract may have important physiological implications.
子宫珠蛋白是一种依赖类固醇激素的低分子量分泌蛋白，具有多种免疫调节特性。这种蛋白质的免疫调节作用可能至少部分与其对磷脂酶A2活性的抑制作用有关。尽管在兔子体内已明确发现子宫珠蛋白，但它在人体内的存在仍存在争议。在此，我们提供了生化和免疫学证据，证明在人类新生儿呼吸道的湿上皮组织中检测到一种类似子宫珠蛋白的蛋白质。由于磷脂酶A2的抑制可能调节组织类花生酸水平，并且由于许多类花生酸（如前列腺素和白三烯等）是平滑肌收缩性、细胞迁移和炎症过程的众所周知的调节因子，因此在人类呼吸道中发现这种蛋白质可能具有重要的生理意义。
