Department of Orthopaedics, Orthopaedic Clinical Research Center of Gansu Province, Intelligent Orthopaedic Industry Technology Center of Gansu Province, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Chengguan District, Lanzhou, 730000, Gansu, People's Republic of China.
Knee Surg Sports Traumatol Arthrosc. 2023 Aug;31(8):3420-3433. doi: 10.1007/s00167-023-07418-8. Epub 2023 Apr 26.
Medial meniscus extrusion (MME) refers to the protrusion of the medial meniscus beyond the tibial edge by more than 3 mm, leading to a deficiency of the hoop strain. MME commonly occurs in conjunction with osteoarthritis (OA) or medial meniscal tears (MMT). However, factors associated with concomitant MME in patients with OA or MMT have not been systematically reviewed. This study aims to perform a systematic review and meta-analysis to identify factors associated with concomitant MME in OA or MMT.
The systematic review of the literature was performed according to PRISMA. A literature search was conducted in 4 databases. All original human studies that reported the available evidence on factors associated with concomitant MME in patients with OA or MMT were included. Pooled binary variables were analyzed by odds ratios (OR) and 95% CIs, and pooled continuous variables were evaluated by mean difference (MD) and 95% CIs.
Ten studies on OA (5993 patients) and eight studies on MMT (872 patients) met the inclusion criteria. The overall pooled incidence of MME was 43% (95% CI, 37-50%) for OA, 61% (95% CI 43-77%) for MMT, and 85% (95% CI 72-94%) for medial meniscal root tears (MMRT). For the population with OA, Factors significantly associated with MME included radiographic OA [OR 4.24; 95% CI 3.07-5.84; P < 0.0001], bone marrow lesions [OR, 3.35; 95% CI 1.61-6.99; P = 0.0013], cartilage damage [OR, 3.25; 95% CI 1.60-6.61; P = 0.0011], and higher body mass index (BMI) [MD, 1.81; 95% CI 1.15-2.48; P < 0.0001]. Factors strongly associated with increased risk of MME for MMT included medial meniscal root [OR, 8.39; 95% CI 2.84-24.82; P < 0.0001] and radial tears [OR, 2.64; 95% CI 1.18-5.92; P < 0.0001].
Radiographic OA, bone marrow lesions, cartilage damage, and higher BMI were significantly associated with concomitant MME with OA. Furthermore, medial meniscal root and radial tears were significantly associated with an increased risk of MME in patients with MMT.
IV.
内侧半月板突出（MME）是指内侧半月板向胫骨边缘突出超过 3 毫米，导致箍应变不足。MME 通常与骨关节炎（OA）或内侧半月板撕裂（MMT）同时发生。然而，与 OA 或 MMT 患者同时发生的 MME 相关的因素尚未得到系统审查。本研究旨在进行系统评价和荟萃分析，以确定与 OA 或 MMT 患者同时发生的 MME 相关的因素。
根据 PRISMA 进行文献系统评价。在 4 个数据库中进行文献检索。纳入了所有报告与 OA 或 MMT 患者同时发生的 MME 相关因素的原始人类研究。通过比值比（OR）和 95%置信区间（CI）分析汇总二分类变量，通过均数差（MD）和 95%CI 评估汇总连续变量。
10 项关于 OA（5993 例患者）和 8 项关于 MMT（872 例患者）的研究符合纳入标准。OA 患者的总体 MME 发生率为 43%（95%CI，37-50%），MMT 为 61%（95%CI，43-77%），内侧半月板根撕裂（MMRT）为 85%（95%CI，72-94%）。对于 OA 患者，与 MME 显著相关的因素包括放射学 OA[OR 4.24；95%CI 3.07-5.84；P<0.0001]、骨髓病变[OR，3.35；95%CI 1.61-6.99；P=0.0013]、软骨损伤[OR，3.25；95%CI 1.60-6.61；P=0.0011]和较高的体重指数（BMI）[MD，1.81；95%CI 1.15-2.48；P<0.0001]。与 MMT 患者 MME 风险增加强烈相关的因素包括内侧半月板根[OR，8.39；95%CI 2.84-24.82；P<0.0001]和放射状撕裂[OR，2.64；95%CI 1.18-5.92；P<0.0001]。
放射学 OA、骨髓病变、软骨损伤和较高的 BMI 与 OA 患者同时发生的 MME 显著相关。此外，内侧半月板根和放射状撕裂与 MMT 患者 MME 风险增加显著相关。
IV。
