Wu Peng
Department of Orthopedics, The Second Affiliated Hospital of Air Force Military Medical University (Tangdu Hospital), 569 Xinsi Road, Baqiao District, Xi'an City, Shaanxi Province, 710000, China.
BMC Musculoskelet Disord. 2024 Dec 30;25(1):1082. doi: 10.1186/s12891-024-08229-9.
To explore the relationship between meniscus compression and the severity of knee osteoarthritis.
A retrospective case-control study included 95 patients with knee osteoarthritis (OA) admitted to our hospital from April 2021 to July 2023, who were grouped into slight protrusion of meniscus group (n = 48) and severe protrusion of meniscus group (n = 47) according to the degree of meniscal extrusion. Various parameters, including Kellgren/Lawrence classification, imaging findings, cartilage damage grading, physical function assessments, and correlation analyses, were used to evaluate the relationship between meniscal extrusion and disease progression.
The study revealed significant associations between severe meniscal extrusion and measures of disease severity, including reduced cartilage thickness(3.24 ± 0.61 versus 3.78 ± 1.45; P = 0.019), increased meniscus degeneration grade (2.86 ± 0.54 versus 2.23 ± 1.63; P = 0.013), diminished joint space width (4.56 ± 0.73 versus 4.86 ± 0.52; P = 0.025), elevated meniscal extrusion(3.68 ± 1.78 versus 2.85 ± 1.54; P = 0.018), greater bone marrow lesion volume(6.13 ± 1.85 versus 5.21 ± 1.58; P = 0.011), advanced cartilage damage(t = 0.016), and impaired physical functioning. Correlation analyses indicated a positive relationship between meniscal extrusion and disease severity(r > 0). While the predictive value of meniscal extrusion alone was modest (AUC = 0.617), a combined model integrating various parameters yielded a high predictive value for disease progression (AUC = 0.853).
Meniscal extrusion was associated with disease severity and functional decline in knee osteoarthritis patients and has potential predictive value for disease progression.
探讨半月板挤压与膝关节骨关节炎严重程度之间的关系。
一项回顾性病例对照研究纳入了2021年4月至2023年7月期间我院收治的95例膝关节骨关节炎（OA）患者，根据半月板挤出程度将其分为半月板轻度突出组（n = 48）和半月板重度突出组（n = 47）。采用包括Kellgren/Lawrence分级、影像学表现、软骨损伤分级、身体功能评估及相关性分析等各种参数来评估半月板挤出与疾病进展之间的关系。
研究显示，严重半月板挤出与疾病严重程度指标之间存在显著关联，包括软骨厚度降低（3.24±0.61对3.78±1.45；P = 0.019）、半月板退变程度增加（2.86±0.54对2.23±1.63；P = 0.013）、关节间隙宽度减小（4.56±0.73对4.86±0.52；P = 0.025）、半月板挤出增加（3.68±1.78对2.85±1.54；P = 0.018）、骨髓病变体积增大（6.13±1.85对5.21±1.58；P = 0.011）、软骨损伤加重（t = 0.016）以及身体功能受损。相关性分析表明半月板挤出与疾病严重程度呈正相关（r > 0）。虽然单独的半月板挤出预测价值一般（AUC = 0.617），但整合各种参数的联合模型对疾病进展具有较高的预测价值（AUC = 0.853）。
半月板挤出与膝关节骨关节炎患者的疾病严重程度和功能下降相关，对疾病进展具有潜在的预测价值。
