光学相干断层扫描技术在儿童视盘测量中的应用

Optic Disc Measurements in Children by Optical Coherence Tomography.

作者信息

Hashemi Hassan, Khabazkhoob Mehdi, Heydarian Samira, Emamian Mohammad Hassan, Fotouhi Akbar

机构信息

Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital.

Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences.

出版信息

J Glaucoma. 2023 May 1;32(5):361-368. doi: 10.1097/IJG.0000000000002159. Epub 2022 Nov 29.

DOI:10.1097/IJG.0000000000002159

PMID:37099446

Abstract

PRCIS

This study showed the distribution of optic disc indices in a population-based sample of Iranian children in detail. Refractive errors and biometric components are among the ocular factors that are related to these indices.

PURPOSE

To determine the normative value of optic nerve indices in children and their association with ocular and demographic factors.

METHODS

A cross-sectional study was conducted in 2018. Biometry was done using the Allegro Biograph, and macular indices were measured by OCT imaging.

RESULTS

After applying the exclusion criteria, 9051 eyes of 4784 children were analyzed. The mean±SD and 95% confidence intervals (in parentheses) of vertical cup-to-disc ratio, average cup-to-disc ratio, rim area, disc area, and cup volume were 0.45±0.15(0.45-0.46) mm, 0.43±0.14 (0.42-0.43) mm, 1.46±0.25 (1.45-1.47) mm 2 , 1.92±0.35 (1.91-1.93) mm 2 , and 0.14±0.14 (0.14-0.15) mm 3 , respectively. Vertical cup-to-disc ratio and average cup-to-disc ratio had a positive association with intraocular pressure (IOP) (both βs=0.003), and a negative association with retinal nerve fiber layer thickness (both βs=-0.001), central corneal thickness (CCT) (both βs=-0.001), anterior chamber depth (β=-0.025 and β=-0.027, respectively), lens thickness (β=-0.034 and β=-0.032, respectively), and mean keratometry (MK) (both βs=-0.015). The average cup-to-disc ratio had a positive association with height (β=0.001). Rim area had a negative association with increased age (β=-0.008), axial length (β=-0.065), IOP (β=-0.009), and MK (β=-0.014) and a positive association with macular volume (β=0.021), retinal nerve fiber layer thickness (β=0.004), and CCT (β=0.001). Disc area had a positive association with macular volume (β=0.031) and a negative association with female sex (β=-0.037), axial length (β=-0.087), anterior chamber depth (β=-0.112), lens thickness (β=-0.059), and MK (β=-0.048). The results of generalized estimating equations showed that cup volume was smaller in girls (β=-0.009), and had a positive association with height (β=0.001), IOP (β=0.003) and negative association with CCT (β=-0.0001) and MK (β=-0.012).

CONCLUSION

The results provided the normative values of optic disc indices in children. Demographic factors, biometric components, IOP, SBP, and retinal parameters had a significant association with optic disc indices.

摘要

PRCIS

本研究详细展示了伊朗儿童基于人群样本的视盘指数分布情况。屈光不正和生物测量成分是与这些指数相关的眼部因素。

目的

确定儿童视神经指数的正常值及其与眼部和人口统计学因素的关联。

方法

2018年进行了一项横断面研究。使用Allegro Biograph进行生物测量，并通过OCT成像测量黄斑指数。

结果

应用排除标准后，对4784名儿童的9051只眼睛进行了分析。垂直杯盘比、平均杯盘比、盘沿面积、视盘面积和杯体积的平均值±标准差及95%置信区间（括号内）分别为0.45±0.15（0.45 - 0.46）mm、0.43±0.14（0.42 - 0.43）mm、1.46±0.25（1.45 - 1.47）mm²、1.92±0.35（1.91 - 1.93）mm²和0.14±0.14（0.14 - 0.15）mm³。垂直杯盘比和平均杯盘比与眼压（IOP）呈正相关（β均为0.003），与视网膜神经纤维层厚度呈负相关（β均为 - 0.001），与中央角膜厚度（CCT）呈负相关（β均为 - 0.001），与前房深度呈负相关（β分别为 - 0.025和 - 0.027），与晶状体厚度呈负相关（β分别为 - 0.034和 - 0.032），与平均角膜曲率（MK）呈负相关（β均为 - 0.015）。平均杯盘比与身高呈正相关（β = 0.001）。盘沿面积与年龄增长呈负相关（β = - 0.008）、与眼轴长度呈负相关（β = - 0.065）、与眼压呈负相关（β = - 0.009）、与平均角膜曲率呈负相关（β = - 0.014），与黄斑体积呈正相关（β = 0.021）、与视网膜神经纤维层厚度呈正相关（β = 0.004）、与中央角膜厚度呈正相关（β = 0.001）。视盘面积与黄斑体积呈正相关（β = 0.031），与女性性别呈负相关（β = - 0.037）、与眼轴长度呈负相关（β = - 0.087）、与前房深度呈负相关（β = - 0.112）、与晶状体厚度呈负相关（β = - 0.059）、与平均角膜曲率呈负相关（β = - 0.048）。广义估计方程的结果显示，杯体积在女孩中较小（β = - 0.009），与身高呈正相关（β = 0.001）、与眼压呈正相关（β = 0.003），与中央角膜厚度呈负相关（β = - 0.0001）、与平均角膜曲率呈负相关（β = - 0.012）。