Courtney K D, Andrews J E, Springer J, Ménache M, Williams T, Dalley L, Graham J A
Fundam Appl Toxicol. 1986 Jan;6(1):145-54. doi: 10.1016/0272-0590(86)90270-8.
Toluene administered by inhalation at 400 ppm to CD-1 mice from Days 6 to 16 of gestation was teratogenic but not fetotoxic resulting in a significant shift in the fetal rib profile. At the lower concentration of 200 ppm, there was an increase in dilated renal pelves which might reflect desynchronization of maturation with respect to development and growth. No other effects were noted at the 200-ppm concentration. At 400 ppm, toluene also produced an increased body weight in the neonates on Day 1 postpartum following in utero exposure. Activity of lactic dehydrogenase (LDH) was significantly increased in the brains of dams exposed to 400 ppm during gestation while nonpregnant adult mice studied concurrently had significant increased activities of LDH in the liver and kidneys of the 400-ppm group. The only change in the isozyme profiles was in the kidneys of the nonpregnant adult mice in which a slight decrease in LDH-2 was observed. No other changes were noted in the dams or pups.
在妊娠第6天至第16天，对CD-1小鼠吸入400 ppm甲苯具有致畸性，但无胚胎毒性，导致胎儿肋骨轮廓发生显著变化。在200 ppm的较低浓度下，肾盂扩张增加，这可能反映了成熟与发育和生长的不同步。在200 ppm浓度下未观察到其他影响。在400 ppm时，甲苯还使子宫内暴露的新生小鼠在出生后第1天体重增加。妊娠期间暴露于400 ppm的母鼠大脑中乳酸脱氢酶（LDH）活性显著增加，而同时研究的未怀孕成年小鼠中，400 ppm组的肝脏和肾脏中LDH活性显著增加。同工酶谱的唯一变化是在未怀孕成年小鼠的肾脏中，观察到LDH-2略有下降。在母鼠或幼崽中未观察到其他变化。
