Skalko R G
Department of Anatomy, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0582.
Environ Health Perspect. 1993 Dec;101 Suppl 6(Suppl 6):143-9. doi: 10.1289/ehp.93101s6143.
The reproductive, developmental, and postnatal toxicity of 14 select chemicals and mixtures that are components of gasoline has been reviewed. The majority of experimental analyses have been performed as either variations of the accepted segment 2 protocol or as traditional teratology studies. Specific deficiencies in the present database have been identified and are most obvious in the evaluation of reproductive and postnatal effects. It is recommended that future studies address the continuing need for assessment in multiple species and over a range of dosages with specific emphasis on the impact of route of administration on the results obtained.
对作为汽油成分的14种特定化学品和混合物的生殖、发育及出生后毒性进行了综述。大多数实验分析是作为公认的第二阶段实验方案的变体进行的，或者是作为传统的致畸学研究。已确定当前数据库中的具体缺陷，这些缺陷在生殖和出生后影响的评估中最为明显。建议未来的研究满足在多个物种和一系列剂量下进行评估的持续需求，特别强调给药途径对所得结果的影响。
