来自细叶山胡椒的具有α-葡萄糖苷酶抑制活性的活性成分。
Active constituents with α-glucosidase inhibitory activities from Sabia parviflora.
机构信息
School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products Research Center of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products Research Center of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
出版信息
Fitoterapia. 2023 Jun;167:105516. doi: 10.1016/j.fitote.2023.105516. Epub 2023 Apr 25.
To identify the active constituents with α-glucosidase inhibitory activities in Sabia parviflora, three new compounds, namely, sabiaparviflora A-C (1, 2 and 8), and seven known compounds were isolated from the plant by repeated column chromatography. The structures of the new compounds were identified by extensive application of spectroscopic methods, including H NMR, C NMR, IR and HR-ESI-MS. All compounds, except for compounds 3-5, 9 and 10 were isolated for the first time from S. parviflora. Their α-glucosidase inhibitory activities were evaluated for the first time by the PNPG method. Three compounds (1, 7 and 10) exhibited marked activities, with IC values ranging from 104 to 324 μM, and their structure-activity relationship is preliminarily discussed herein.
为了从细梗香草（Sabia parviflora）中鉴定出具有α-葡萄糖苷酶抑制活性的活性成分，通过反复的柱层析从该植物中分离得到了三个新化合物，分别为 sabiaparviflora A-C（1、2 和 8），以及七个已知化合物。通过广泛应用包括 H NMR、C NMR、IR 和 HR-ESI-MS 在内的光谱方法，确定了新化合物的结构。除了化合物 3-5、9 和 10 之外，所有化合物均为首次从细梗香草中分离得到。首次通过 PNPG 法评估了它们的α-葡萄糖苷酶抑制活性。三个化合物（1、7 和 10）表现出显著的活性，IC 值范围为 104-324 μM，初步讨论了它们的构效关系。
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