川木香根中的齐墩果烷型三萜皂苷及其α-葡萄糖苷酶抑制活性。

College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Molecules. 2017 Nov 17;22(11):1981. doi: 10.3390/molecules22111981.

Five new oleanane-type saponins, named ligushicosides A-E, and three known oleanane-type saponins were isolated from the roots of . Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast -glucosidase inhibitory effects and exhibited potent inhibition against -glucosidase, while compounds and showed excellent inhibitory activities. The 3--glycoside moiety in oleanane-type saponin is important for the -glucosidase inhibitory effects.

从. 的根部分离得到了五个新的齐墩果烷型皂苷，命名为 ligushicosides A-E，以及三个已知的齐墩果烷型皂苷。通过光谱技术，包括 1D 和 2D NMR 以及高分辨率电喷雾电离质谱（HR-ESI-MS），确定了它们的结构。此外，还评估了所有分离物对酵母 -葡萄糖苷酶的抑制作用，结果表明它们对 -葡萄糖苷酶具有很强的抑制作用，而化合物和表现出极好的抑制活性。齐墩果烷型皂苷中的 3-O-糖苷部分对于 -葡萄糖苷酶抑制作用很重要。