Faculty of Science and Engineering, Waseda University, Tokyo, Japan.
New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan.
Sci Rep. 2023 Apr 26;13(1):4955. doi: 10.1038/s41598-023-31748-9.
High-resolution imaging of alpha particles is required in the detection of alpha radionuclides in cells or small organs for the development of radio-compounds for targeted alpha-particle therapy or other purposes. We developed an ultrahigh resolution, real time alpha-particle imaging system for observing the trajectories of alpha particles in a scintillator. The developed system is based on a magnifying unit and a cooled electron multiplying charge-coupled device (EM-CCD) camera, combined with a 100-µm-thick Ce-doped GdAlGaO (GAGG) scintillator plate. Alpha particles from an Am-241 source were irradiated to the GAGG scintillator and imaged with the system. Using our system, we measured the trajectories of the alpha particles having different shapes in real time. In some of these measured trajectories, the line shapes of the alpha particles that flew in the GAGG scintillator were clearly observed. The lateral profiles of the alpha-particle trajectories were imaged with widths of ~ 2 µm. We conclude that the developed imaging system is promising for research on targeted alpha-particle therapy or other alpha particle detections that require high spatial resolution.
在开发用于靶向 alpha 粒子治疗或其他需要高空间分辨率的 alpha 粒子检测的放射性化合物时，需要在细胞或小器官中检测 alpha 放射性核素，这就需要高分辨率的 alpha 粒子成像。我们开发了一种超高分辨率、实时 alpha 粒子成像系统，用于观察闪烁体中 alpha 粒子的轨迹。所开发的系统基于一个放大单元和一个冷却的电子倍增电荷耦合器件（EM-CCD）相机，结合了一个 100-μm 厚的掺铈钆铝镓氧化物（GAGG）闪烁体板。用 Am-241 源照射 GAGG 闪烁体，并使用该系统对其进行成像。使用我们的系统，我们实时测量了具有不同形状的 alpha 粒子的轨迹。在这些测量轨迹中的一些轨迹中，清楚地观察到了在 GAGG 闪烁体中飞行的 alpha 粒子的线形状。alpha 粒子轨迹的横向轮廓以约 2μm 的宽度成像。我们得出结论，所开发的成像系统有望用于靶向 alpha 粒子治疗或其他需要高空间分辨率的 alpha 粒子检测的研究。
