Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Chin Med J (Engl). 2023 Jun 5;136(11):1311-1321. doi: 10.1097/CM9.0000000000002620.
It remains unclear whether circulating malondialdehyde (MDA) levels change in people with diabetic retinopathy (DR). This systematic review compared circulating MDA levels in diabetic people with and without DR.
PubMed, Medline (Ovid), Embase (Ovid), and Web of Science were searched for case-control studies conducted before May 2022 in English that compared circulating MDA levels in people with and without DR. The following MeSH search terms were used: ("malondialdehyde" or "thiobarbituric acid reactive substances [TBARS]" or "lipid peroxidation" or "oxidative stress") and "diabetic retinopathy." Newcastle-Ottawa Quality Assessment Scale was used to evaluate the quality of the included studies. Random-effects pairwise meta-analysis pooled the effect size with standardized mean difference (SMD) and 95% confidence intervals (CIs).
This meta-analysis included 29 case-control studies with 1680 people with DR and 1799 people with diabetes but not DR. Compared to people without DR, the circulating MDA levels were higher in those with DR (SMD, 0.897; 95% CI, 0.631 to 1.162; P < 0.001). The study did not identify credible subgroup effects or publication bias and the sensitivity analysis confirmed the robustness of the study.
Circulating MDA levels are higher in people with DR compared to those without. Future comparative studies that use more specific methods are required to draw firm conclusions.
PROSPERO; https://www.crd.york.ac.uk/PROSPERO/ ; No. CRD42022352640.
目前尚不清楚患有糖尿病视网膜病变（DR）的人循环中的丙二醛（MDA）水平是否会发生变化。本系统评价比较了患有和不患有 DR 的糖尿病患者的循环 MDA 水平。
检索了 2022 年 5 月之前发表的英文病例对照研究，这些研究比较了患有和不患有 DR 的糖尿病患者的循环 MDA 水平。使用了以下 MeSH 搜索词：（“丙二醛”或“硫代巴比妥酸反应物质 [TBARS]”或“脂质过氧化”或“氧化应激”）和“糖尿病视网膜病变”。纽卡斯尔-渥太华质量评估量表用于评估纳入研究的质量。随机效应成对荟萃分析用标准化均数差（SMD）和 95%置信区间（CI）合并效应大小。
本荟萃分析纳入了 29 项病例对照研究，共纳入 1680 例 DR 患者和 1799 例无 DR 的糖尿病患者。与无 DR 的患者相比，DR 患者的循环 MDA 水平更高（SMD，0.897；95%CI，0.631 至 1.162；P ＜0.001）。该研究未发现可信的亚组效应或发表偏倚，敏感性分析证实了研究的稳健性。
与无 DR 的患者相比，DR 患者的循环 MDA 水平更高。需要进行使用更具体方法的未来比较研究以得出确切结论。
PROSPERO；https://www.crd.york.ac.uk/PROSPERO/ ；注册号 CRD42022352640。
