Jiang Yanhua, Fan Huaying, Xie Jing, Xu Yao, Sun Xin
Department of Ophthalmology, Fourth People's Hospital of Shenyang, Shenyang, China.
Department of Endocrinology and Metabolism, First Affiliated Hospital of Soochow University, Suzhou, China.
Front Endocrinol (Lausanne). 2023 Oct 6;14:1271027. doi: 10.3389/fendo.2023.1271027. eCollection 2023.
Diabetic retinopathy (DR) is a common complication of diabetes. The adipocytokines are closely associated with the occurrence and development of diabetes and its related complications. Literature confirms that the level of adiponectin in patients with DR is significantly higher; however, the relationship between other adipocytokines (leptin, chemerin, apelin, and omentin-1) and DR remains unclear.
This study aimed to systematically evaluate the association between adipocytokines (leptin, chemerin, apelin, and omentin-1) and DR.
The PubMed, Web of Science, Embase, EBSCO and Willy databases were used to search for potential studies with keywords such as "diabetic retinopathy" or "DR" in combination with the terms "leptin," "chemerin", "apelin" or "omentin-1" in the search titles or abstracts. Standardized mean differences (SMD) with corresponding 95% confidence intervals (CIs) were determined as the results of the meta-analysis.
After screening, 18 articles were included in the meta-analysis including 750 DR cases and 993 controls. Leptin and chemerin levels in patients with DR were significantly higher than those in the control group (SMD: 0.68, 95% CI [0.1, 1.26]; SMD: 0.79, 95% CI [0.35, 1.23]). The omentin-1 levels in patients with DR were significantly lower than those in the controls (SMD: -0.85, 95% CI [-1.08, -0.62]).
To the best of our knowledge, this is the first meta-analysis to evaluate the leptin, chemerin, apelin, and omentin-1 levels in patients with DR. Further high-quality studies are warranted to support the association between these adipocytokines and DR.
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=443770, identifier CRD42023443770.
糖尿病视网膜病变（DR）是糖尿病常见的并发症。脂肪细胞因子与糖尿病及其相关并发症的发生和发展密切相关。文献证实，DR患者脂联素水平显著升高；然而，其他脂肪细胞因子（瘦素、趋化素、Apelin和网膜素-1）与DR之间的关系仍不清楚。
本研究旨在系统评价脂肪细胞因子（瘦素、趋化素、Apelin和网膜素-1）与DR之间的关联。
使用PubMed、Web of Science、Embase、EBSCO和Willy数据库，以搜索标题或摘要中含有“糖尿病视网膜病变”或“DR”，并与“瘦素”、“趋化素”、“Apelin”或“网膜素-1”等词组合的潜在研究。标准化均数差（SMD）及其相应的95%置信区间（CI）作为荟萃分析的结果。
筛选后，18篇文章纳入荟萃分析，包括750例DR病例和993例对照。DR患者的瘦素和趋化素水平显著高于对照组（SMD：0.68，95%CI[0.1，1.26]；SMD：0.79，95%CI[0.35，1.23]）。DR患者的网膜素-1水平显著低于对照组（SMD：-0.85，95%CI[-1.08，-0.62]）。
据我们所知，这是第一项评估DR患者瘦素、趋化素、Apelin和网膜素-1水平的荟萃分析。需要进一步的高质量研究来支持这些脂肪细胞因子与DR之间的关联。
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=443770，标识符CRD42023443770。
