Bonaïti C, Demenais F, Bois E, Hochez J
Genet Epidemiol. 1986;3(2):113-9. doi: 10.1002/gepi.1370030206.
Hearing troubles were found to be very frequent among inhabitants of French origin in a small Caribbean island. Segregation analysis of hearing loss was performed in 165 complete nuclear families and revealed that familial aggregation could be entirely explained by a single recessive gene with high frequency (0.40). Homozygous individuals for this gene would probably be more susceptible to ototoxic agents than other individuals. High frequency of this gene may be due to a founder effect.
在一个加勒比小岛上，人们发现法裔居民中听力问题非常普遍。对165个完整的核心家庭进行了听力损失的分离分析，结果显示家族聚集现象完全可以由一个高频隐性基因（0.40）来解释。该基因的纯合个体可能比其他个体更容易受到耳毒性药物的影响。这个基因的高频率可能是由于奠基者效应。
