Clark A G, Feldman M W
Genetics. 1986 May;113(1):161-76. doi: 10.1093/genetics/113.1.161.
Numerical simulations were performed to determine the equilibrium behavior of the one-locus fertility model in which fitness is considered as a property of a pair of mating diploids. A series of patterns of "fertility matrices" were considered for a single locus with two to six alleles. From these simulations, 19 different statistics were collected that characterize, at equilibrium, the heterozygosity, the mean fitness and the fate of populations begun at the allele-frequency centroid. For more than one-half of the trajectories produced by random fertility matrices, there was a decrease in the mean fitness at some time on the way to equilibrium. The mean number of alleles maintained at equilibrium increased only slightly with matrix dimension. Despite the potential for fertility models to display multiple stable equilibria, random fertility models maintain fewer distinct stable points than do random one-locus viability models. Pleiotropic models were also considered with fertility and viability selection operating sequentially within each generation. Most of the equilibrium statistics (with the exception of mean fertility) for the pleiotropic model were intermediate between the corresponding random viability and fertility models.
进行了数值模拟，以确定单基因座育性模型的平衡行为，其中适合度被视为一对交配二倍体的一种属性。对于具有2至6个等位基因的单个基因座，考虑了一系列“育性矩阵”模式。从这些模拟中，收集了19种不同的统计量，这些统计量在平衡时表征了杂合性、平均适合度以及从等位基因频率质心开始的种群的命运。对于由随机育性矩阵产生的超过一半的轨迹，在达到平衡的过程中的某个时间，平均适合度会下降。平衡时维持的等位基因平均数仅随矩阵维度略有增加。尽管育性模型有可能显示多个稳定平衡点，但随机育性模型比随机单基因座生存力模型维持的不同稳定点更少。还考虑了多效性模型，其中育性和生存力选择在每一代中依次起作用。多效性模型的大多数平衡统计量（平均育性除外）介于相应的随机生存力模型和育性模型之间。
