Spencer H G, Marks R W
Department of Biological Sciences, Stanford University, California 94305.
Genetics. 1988 Oct;120(2):605-13. doi: 10.1093/genetics/120.2.605.
The ability of viability selection to maintain single-locus polymorphism is investigated with two models in which the population is bombarded with a series of mutations with random fitnesses. In the first model, the population is allowed to reach equilibrium before mutation resumes; in the second the iterations and mutation occur simultaneously. Monte Carlo simulations of these models show that viability selection is easily able to maintain stable 6- or 7-allele polymorphisms and that monomorphisms and diallelic polymorphisms are uncommon. The question of how monomorphisms arise is also discussed.
利用两个模型研究了生存力选择维持单基因座多态性的能力，在这两个模型中，群体受到一系列具有随机适合度的突变的冲击。在第一个模型中，群体在突变恢复之前被允许达到平衡；在第二个模型中，迭代和突变同时发生。对这些模型的蒙特卡洛模拟表明，生存力选择很容易维持稳定的6或7等位基因多态性，而单态性和双等位基因多态性并不常见。还讨论了单态性如何产生的问题。
