抗真菌药物研发与将真菌疾病对公共卫生的影响降至最低的紧迫性。
Antifungal Development and the Urgency of Minimizing the Impact of Fungal Diseases on Public Health.
作者信息
de Oliveira Haroldo C, Bezerra Bárbara T, Rodrigues Marcio L
机构信息
Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba81310-020, Brazil.
Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, Rio de Janeiro21941-902, Brazil.
出版信息
ACS Bio Med Chem Au. 2022 Nov 18;3(2):137-146. doi: 10.1021/acsbiomedchemau.2c00055. eCollection 2023 Apr 19.
Fungal infections are a major public health problem resulting from the lack of public policies addressing these diseases, toxic and/or expensive therapeutic tools, scarce diagnostic tests, and unavailable vaccines. In this Perspective, we discuss the need for novel antifungal alternatives, highlighting new initiatives based on drug repurposing and the development of novel antifungals.
真菌感染是一个重大的公共卫生问题，其原因在于缺乏针对这些疾病的公共政策、治疗工具有毒和/或昂贵、诊断测试稀缺以及没有可用的疫苗。在这篇观点文章中，我们讨论了新型抗真菌替代方案的必要性，重点介绍了基于药物重新利用和新型抗真菌药物开发的新举措。
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