Sanyaolu Adekunle, Okorie Chuku, Marinkovic Aleksandra, Abbasi Abu Fahad, Prakash Stephanie, Mangat Jasmine, Hosein Zaheeda, Haider Nafees, Chan Jennifer
Federal Ministry of Health, Abuja, Nigeria.
Union County College, Plainfield Campus, Plainfield, NJ, USA.
Infect Chemother. 2022 Jun;54(2):236-246. doi: 10.3947/ic.2022.0008.
is an invasive fungal pathogen that has been recognized globally as a serious health threat due to its extensive innate and acquired resistance to antifungal drugs. A growing number of emerging cases of have been reported with resistance to the standard antifungal treatments including azoles, echinocandins, and polyenes, making it difficult to treat. Unlike other species, is challenging to diagnose using the standard laboratory methods and are typically prone to misidentification, resulting in inappropriate management. Consequently, infections have spread globally. The Centers for Disease Control and Prevention data showed that clinical cases of increased from 329 in 2018 to 1,012 in 2021. The incidence and prevalence of this invasive fungal infection are high in immunocompromised and hospitalized patients. Patients who had an organ transplant, are on immunosuppressive agents, are diabetic, recent antibiotic use, catheter use, and prolonged hospital or nursing homestays are vulnerable to infections. is rapidly spreading across healthcare settings globally and monitoring of its virulence as well as devising appropriate treatment approaches are thus highly required.
是一种侵袭性真菌病原体,由于其对抗真菌药物具有广泛的固有和获得性耐药性,已被全球公认为对健康的严重威胁。越来越多新出现的病例报告显示对包括唑类、棘白菌素类和多烯类在内的标准抗真菌治疗产生耐药性,使其难以治疗。与其他物种不同,使用标准实验室方法诊断具有挑战性,并且通常容易出现错误识别,导致管理不当。因此,感染已在全球范围内蔓延。疾病控制和预防中心的数据显示,临床病例从2018年的329例增加到2021年的1012例。这种侵袭性真菌感染在免疫功能低下和住院患者中的发病率和患病率很高。接受器官移植、使用免疫抑制剂、患有糖尿病、近期使用抗生素、使用导管以及长期住院或入住疗养院的患者易感染。正在全球医疗环境中迅速传播,因此迫切需要监测其毒力并制定适当的治疗方法。