Miller Assia, Joseph Shalu, Badran Ahmed, Umpaichitra Vatcharapan, Bargman Renee, Chin Vivian L
Department of Pediatrics, Division of Pediatric Endocrinology, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA.
New York City/Health+Hospitals Corporation, Kings County Hospital, Brooklyn, NY 11203, USA.
Int J Pediatr. 2023 Apr 17;2023:4580809. doi: 10.1155/2023/4580809. eCollection 2023.
Following reports of increased new-onset diabetes and worse severity of DKA for children with diabetes following SARS-CoV-2 infection, we studied hospitalization rates for children with type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in our center during the citywide shutdown. . We conducted a retrospective chart review of children admitted to our two hospitals from January 1, 2018, to December 31, 2020. We included ICD-10 codes for diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar syndrome (HHS), and hyperglycemia only. . We included 132 patients with 214 hospitalizations: 157 T1DM, 41 T2DM, and 16 others (14 steroid induced, 2 MODY). Overall admissions rates for patients with all types of diabetes were 3.08% in 2018 to 3.54% in 2019 ( = 0.0120) and 4.73% in 2020 ( = 0.0772). Although there was no increase of T1DM admissions across all 3 years, T2DM admission rates increased from 0.29% to 1.47% ( = 0.0056). Newly diagnosed T1DM rates increased from 0.34% in 2018 to 1.28% ( = 0.002) in 2020, and new-onset T2DM rates also increased from 0.14% in 2018 to 0.9% in 2020 ( = 0.0012). Rates of new-onset diabetes presenting with DKA increased from 0.24% in 2018 to 0.96% in 2020 ( = 0.0014). HHS increased from 0.1% in 2018 to 0.45% in 2020 ( = 0.044). The severity of DKA in newly diagnosed was unaffected ( = 0.1582). Only 3 patients tested positive for SARS-CoV-2 infection by PCR. . Our urban medical center is located in Central Brooklyn and serves a majority who are Black. This is the first study investigating pediatric diabetes cases admitted to Brooklyn during the first wave of the pandemic. Despite the overall pediatric admissions declining in 2020 due to the citywide shutdown, overall hospitalization rates in children with T2DM and in new-onset T1DM and T2DM increased, which is not directly associated with active SARS-CoV-2 infection. More studies are needed to elucidate the reason for this observed increase in hospitalization rates.
有报告称，感染SARS-CoV-2后的糖尿病儿童新发糖尿病增加且糖尿病酮症酸中毒（DKA）严重程度加重，我们研究了全市封锁期间本中心1型糖尿病（T1DM）和2型糖尿病（T2DM）儿童的住院率。我们对2018年1月1日至2020年12月31日期间入住我们两家医院的儿童进行了回顾性病历审查。我们纳入了糖尿病酮症酸中毒（DKA）、高血糖高渗综合征（HHS）和仅高血糖的ICD-10编码。我们纳入了132例患者的214次住院：157例T1DM、41例T2DM和16例其他情况（14例类固醇诱导、2例青少年发病的成年型糖尿病）。各类糖尿病患者的总体住院率在2018年为3.08%，2019年为3.54%（P = 0.0120），2020年为4.73%（P = 0.0772）。虽然在这3年中T1DM的住院人数没有增加，但T2DM的住院率从0.29%增加到了1.47%（P = 0.0056）。新诊断的T1DM率从2018年的0.34%增加到2020年的1.28%（P = 0.002），新发T2DM率也从2018年的0.14%增加到2020年的0.9%（P = 0.0012）。以DKA表现的新发糖尿病率从2018年的0.24%增加到2020年的0.96%（P = 0.0014）。HHS从2018年的0.1%增加到2020年的0.45%（P = 0.044）。新诊断的DKA严重程度未受影响（P = 0.1582）。仅3例患者通过PCR检测SARS-CoV-2感染呈阳性。我们的城市医疗中心位于布鲁克林中部，服务对象大多数是黑人。这是第一项调查疫情第一波期间布鲁克林收治的儿科糖尿病病例的研究。尽管由于全市封锁2020年儿科总体住院人数下降，但T2DM以及新诊断的T1DM和T2DM儿童的总体住院率有所增加，这与SARS-CoV-2的活跃感染没有直接关联。需要更多研究来阐明观察到的住院率增加的原因。
