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强化住院治疗与创新的出院后高压氧治疗康复相结合治疗福尼尔坏疽的进展：病例报告

Advances in Management of Fournier's Gangrene by Coupling Intensive Hospital Treatment With Innovative Post-discharge Hyperbaric Oxygen Therapy Rehabilitation: A Case Report.

作者信息

Wójcik Barbara, Superata Jerzy, Tuleja Tomasz, Kobielska Ewa, Szyguła Zbigniew

机构信息

Department of Clinical Rehabilitation, University of Physical Education, Krakow, POL.

Burns and Plastic Surgery Centre of Malopolska, Department of Adult Plastic and Reconstructive Surgery, Ludwik Rydygier Memorial Hospital, Krakow, POL.

出版信息

Cureus. 2023 Mar 24;15(3):e36639. doi: 10.7759/cureus.36639. eCollection 2023 Mar.

DOI:10.7759/cureus.36639
PMID:37101986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10123327/
Abstract

Fournier's gangrene (FG) is a rare form of necrotizing soft tissue infection characterized by an acute, aggressive, and rapidly progressive course. In this case report, we describe advanced therapy combining critical care, surgery, pharmacotherapy, extended biochemical/cellular blood diagnostics, and post-discharge hyperbaric oxygen therapy rehabilitation. Such an intervention resulted in survival and improved health status and quality of life of the patient with FG and septic shock.

摘要

福尼尔坏疽（FG）是一种罕见的坏死性软组织感染形式，其特点是病程急性、侵袭性强且进展迅速。在本病例报告中，我们描述了一种综合重症监护、手术、药物治疗、扩展的生化/细胞血液诊断以及出院后高压氧治疗康复的先进疗法。这种干预措施使患有FG和感染性休克的患者得以存活，并改善了其健康状况以及生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f0/10123327/4a0a9dcfa555/cureus-0015-00000036639-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f0/10123327/cf0b542dfd4b/cureus-0015-00000036639-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f0/10123327/d1457466164e/cureus-0015-00000036639-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f0/10123327/4a0a9dcfa555/cureus-0015-00000036639-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f0/10123327/cf0b542dfd4b/cureus-0015-00000036639-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f0/10123327/d1457466164e/cureus-0015-00000036639-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f0/10123327/4a0a9dcfa555/cureus-0015-00000036639-i03.jpg

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1
Advances in Management of Fournier's Gangrene by Coupling Intensive Hospital Treatment With Innovative Post-discharge Hyperbaric Oxygen Therapy Rehabilitation: A Case Report.强化住院治疗与创新的出院后高压氧治疗康复相结合治疗福尼尔坏疽的进展：病例报告
Cureus. 2023 Mar 24;15(3):e36639. doi: 10.7759/cureus.36639. eCollection 2023 Mar.
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Outcome of necrotizing fasciitis and Fournier's gangrene with and without hyperbaric oxygen therapy: a retrospective analysis over 10 years.伴有和不伴有高压氧治疗的坏死性筋膜炎和 Fournier 坏疽的转归：10 年回顾性分析。
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Fournier's gangrene: its management remains a challenge.Fournier 坏疽：其治疗仍然是一个挑战。
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Significance of Hyperbaric Oxygenation in the Treatment of Fournier's Gangrene: A Comparative Study.高压氧疗在福尼尔坏疽治疗中的意义：一项对比研究
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引用本文的文献

1
Fournier gangrene - would you KISS it?福尼尔坏疽——你会用简单直接的方式处理它吗？ （注：这里KISS取其Keep It Simple, Stupid首字母缩写的含义，直译为简单直接处理，意译的话可根据语境调整为更符合逻辑通顺的表达，这里只是根据要求进行字面翻译。）
GMS Interdiscip Plast Reconstr Surg DGPW. 2023 Dec 11;12:Doc12. doi: 10.3205/iprs000182. eCollection 2023.

本文引用的文献

1
Progress in Multidisciplinary Treatment of Fournier's Gangrene.福尼尔坏疽的多学科治疗进展
Infect Drug Resist. 2022 Nov 28;15:6869-6880. doi: 10.2147/IDR.S390008. eCollection 2022.
2
How likely is septic shock to develop in a patient with Fournier's gangrene? A risk prediction model based on a 7-year retrospective study.患有福尼尔坏疽的患者发生感染性休克的可能性有多大？基于一项7年回顾性研究的风险预测模型。
Gastroenterol Rep (Oxf). 2022 Aug 11;10:goac038. doi: 10.1093/gastro/goac038. eCollection 2022.
3
The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis.
高压氧对氧化应激、炎症和血管生成的影响。
Biomolecules. 2021 Aug 14;11(8):1210. doi: 10.3390/biom11081210.
4
Energetic dysfunction in sepsis: a narrative review.脓毒症中的能量代谢功能障碍：一项叙述性综述
Ann Intensive Care. 2021 Jul 3;11(1):104. doi: 10.1186/s13613-021-00893-7.
5
Dysregulated Immunity and Immunotherapy after Sepsis.脓毒症后的免疫失调与免疫治疗
J Clin Med. 2021 Apr 17;10(8):1742. doi: 10.3390/jcm10081742.
6
Hyperbaric oxygen treatment is associated with a decrease in cytokine levels in patients with necrotizing soft-tissue infection.高压氧治疗与坏死性软组织感染患者细胞因子水平降低有关。
Physiol Rep. 2021 Mar;9(6):e14757. doi: 10.14814/phy2.14757.
7
The complete blood count to diagnose septic shock.全血细胞计数用于诊断脓毒性休克。
J Thorac Dis. 2020 Feb;12(Suppl 1):S16-S21. doi: 10.21037/jtd.2019.12.63.
8
Mortality associated with Fournier's gangrene remains unchanged over 25 years.25 年来，Fournier 坏疽相关死亡率保持不变。
BJU Int. 2020 Apr;125(4):610-616. doi: 10.1111/bju.14998. Epub 2020 Feb 17.
9
[Fournier's gangrene as special form of necrotizing fasciitis].[福尼尔坏疽作为坏死性筋膜炎的特殊形式]
Chirurg. 2020 Apr;91(4):307-312. doi: 10.1007/s00104-019-01095-5.
10
Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis.治疗坏死性软组织感染时时间至关重要：系统评价和荟萃分析。
World J Emerg Surg. 2020 Jan 8;15:4. doi: 10.1186/s13017-019-0286-6. eCollection 2020.