当前关于 G. Forst.-A 有价值的民间药物治疗潜力的趋势和未来展望。
Current Trends and Future Prospects on the Therapeutic Potential of G. Forst.-A Valuable Folk Medicine.
机构信息
Department of Pharmaceutical Sciences, Sushruta School of Medical and Paramedical Sciences, Assam University (A Central University), Silchar, 788 011, Assam, India.
出版信息
Curr Top Med Chem. 2023;23(17):1579-1605. doi: 10.2174/1568026623666230427114318.
BACKGROUND
G. Forst (Boraginaceae), usually recognized as Clammy/ Indian cherry, is a familiar Ayurvedic, Unani, and modern herbal medicine used for diverse unrelated ailments since antiquity. It is rich in phytochemical constituents, has nutritional significance, and possesses enormous pharmacological properties.
OBJECTIVE
This review has been established to highlight the importance of G. Forst by providing comprehensive knowledge of its phytochemical, ethnobotanical, pharmacological, and toxicological aspects with a perception to foster pharmaceutical research to exploit its maximum potential as a therapeutic agent.
METHODS
Literature research has been accomplished using Google Scholar and databases like Science Direct, WOS, PubMed, SciFinder, Scopus with updates until June 2022.
RESULTS
The work is an update on G. and it reviewed and analyzed its phytochemical, ethnobotanical, pharmacological and toxicological knowledge from early human communities to contemporary medicinal and pharmaceutical applications with comprehensive examination of myriad plausible applications in the present-day scientific milieu. The species depicted the presence of diverse phytochemical profiles, possibly justifying its bioactive potential.
CONCLUSION
This review will help lay grounds to facilitate state-of-art research intended to acquire additional information about the plant. The study offers opportunities to explore bio-guided isolation strategies for isolating and purifying phytochemical constituents that are biologically effective including pharmacological and pharmaceutical aspects to better understand its clinical relevance. Exploring pure isolated phytoconstituents for their mode of action including estimation of their bioavailability and pharmacokinetic parameters would be of considerable interest in assessing the attained pharmacological effect. Clinical studies are required to validate the suitability of its traditional usage.
背景
G. Forst（紫草科），通常被认作葛缕子/印度樱桃，是一种在古已有之的阿育吠陀、顺势疗法和现代草药学中广泛使用的草药，用于治疗各种不同的疾病。它富含植物化学成分，具有营养价值，并具有巨大的药理学特性。
目的
本综述旨在通过提供其植物化学、民族植物学、药理学和毒理学方面的综合知识，强调 G. Forst 的重要性，以期促进药物研究，以充分发挥其作为治疗剂的潜力。
方法
使用 Google Scholar 和数据库（如 Science Direct、WOS、PubMed、SciFinder、Scopus）进行文献研究，更新截至 2022 年 6 月。
结果
这项工作是对 G. 的更新，综述和分析了其从早期人类社会到当代医学和药物应用的植物化学、民族植物学、药理学和毒理学知识，全面考察了当今科学环境中无数可能的应用。该物种表现出多样化的植物化学成分，这可能证明了其生物活性潜力。
结论
本综述将有助于为旨在获取有关该植物更多信息的最新研究奠定基础。该研究为探索生物导向的分离策略提供了机会，以分离和纯化具有生物活性的植物化学成分，包括药理学和药物学方面，以更好地理解其临床相关性。探索具有生物活性的纯植物化学成分的作用模式，包括估计其生物利用度和药代动力学参数，对于评估所获得的药理作用将具有相当大的意义。需要进行临床研究来验证其传统用途的适用性。
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