评估宫颈癌患者的 CD4+:CD8+ 比值和炎症标志物水平。
Evaluation of CD4+:CD8+ Ratio in Patients With Cervical Cancer and the Levels of Inflammatory Markers.
机构信息
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Kingdom of Saudi Arabia;
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Kingdom of Saudi Arabia.
出版信息
In Vivo. 2022 Sep-Oct;36(5):2414-2421. doi: 10.21873/invivo.12975.
BACKGROUND/AIM: Cervical cancer remains a major public health concern. The ratio of CD4+:CD8+ T-cells is used to evaluate the immune system function. This study aimed to explore the CD4+:CD8+ T-cell ratio in relation to the glycemic status, inflammatory markers, vitamin D, and vitamin B12 in patients with early diagnosed cervical cancer.
PATIENTS AND METHODS
This is a cross-sectional study. Blood samples were collected for flow cytometry analysis. Information regarding Papanicolaou (Pap) smears and colposcopy investigations were collected from 152 women with type 2 diabetes admitted to East Jeddah Hospital, Jeddah, Saudi Arabia, between January 2018 and January 2021.
RESULTS
Patients with early cervical carcinoma and a higher CD4+:CD8+ ratio (>1.2) had a higher C-reactive protein (CRP) level than those with a lower CD4+:CD8+ ratio (Mean±SD=13.75±13.3 vs. 10.85±8.1; p-value=0.034). Patients with early cervical carcinoma, diabetes, and higher CD4+:CD8+ ratio (>1.2) had a higher blood HbA1c percent than those with a lower CD4+:CD8+ ratio.
CONCLUSION
A high CD4+:CD8+ T-cells ratio was associated with an increased HbA1c% and CRP levels in women with diabetes diagnosed with early cervical carcinoma, which can induce inflammation in early diagnosed patients with cervical cancer.
背景/目的：宫颈癌仍然是一个主要的公共卫生问题。CD4+：CD8+ T 细胞的比值用于评估免疫系统功能。本研究旨在探讨 CD4+：CD8+ T 细胞比值与早期诊断宫颈癌患者的血糖状态、炎症标志物、维生素 D 和维生素 B12 的关系。
患者和方法
这是一项横断面研究。采集血样进行流式细胞术分析。2018 年 1 月至 2021 年 1 月期间，从沙特阿拉伯吉达市东吉达医院收治的 152 例 2 型糖尿病女性患者中收集了有关巴氏涂片和阴道镜检查的信息。
结果
与 CD4+：CD8+ 比值较低（<1.2）的患者相比，早期宫颈癌且 CD4+：CD8+ 比值较高（>1.2）的患者 C 反应蛋白（CRP）水平更高（均值±标准差=13.75±13.3 与 10.85±8.1；p 值=0.034）。患有早期宫颈癌、糖尿病和 CD4+：CD8+ 比值较高（>1.2）的患者的血液 HbA1c%高于 CD4+：CD8+ 比值较低的患者。
结论
在患有糖尿病且被诊断为早期宫颈癌的女性中，高 CD4+：CD8+ T 细胞比值与 HbA1c%和 CRP 水平升高相关，这可能会在早期诊断的宫颈癌患者中引发炎症。
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