Kim Hyun Jung, Kim Eun Jin, Choi Jee Woong, Kim You Chan, Lee Hee-Il, Shin Hyun-Il
Division of Vectors and Parasitic Diseases, Korea Disease Control and Prevention Agency, Cheongju 28159, Republic of Korea.
Department of Medical Science and Infectious Biology, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea.
Trop Med Infect Dis. 2023 Apr 12;8(4):223. doi: 10.3390/tropicalmed8040223.
Leishmaniasis is a neglected tropical disease and an infectious disease transmitted by sandflies that occurs worldwide. In the absence of physicians seeking to identify the causes of disease in non-endemic areas, appropriate diagnoses cannot be made, thereby hampering effective treatment. In this report, we examined a nodular lesion on a patient's chin by performing a biopsy and molecular analysis. The biopsy finding led to the identification of a amastigote. On the basis of PCR analysis of the internal transcribed spacer 1 gene and 5.8 S ribosomal RNA with a subsequent BLAST search, we identified the causal organism as . The patient, who had visited Spain from 1 July to 31 August 2018, was accordingly diagnosed with cutaneous leishmaniasis and was administered liposomal amphotericin B, which successfully treated the skin lesion. Travel history plays an important role in the diagnosis of leishmaniasis, and physicians should bear in mind that travelers can also introduce diseases and pathogens to non-endemic areas. Identification of at the species level will increase the efficacy of treatment.
利什曼病是一种被忽视的热带疾病，是由白蛉传播的一种传染病，在全球范围内均有发生。在非流行地区，如果没有医生试图确定疾病病因，就无法做出恰当诊断，从而阻碍有效治疗。在本报告中，我们通过活检和分子分析对一名患者下巴上的结节性病变进行了检查。活检结果发现了无鞭毛体。基于对内部转录间隔区1基因和5.8S核糖体RNA的PCR分析以及随后的BLAST搜索，我们确定病原体为……。该患者于2018年7月1日至8月31日访问了西班牙，因此被诊断为皮肤利什曼病，并接受了脂质体两性霉素B治疗，成功治愈了皮肤病变。旅行史在利什曼病的诊断中起着重要作用，医生应牢记旅行者也可能将疾病和病原体引入非流行地区。在物种水平上鉴定……将提高治疗效果。
