Soila K, Nummi P, Ekfors T, Viamonte M, Kormano M
Invest Radiol. 1986 May;21(5):411-5. doi: 10.1097/00004424-198605000-00010.
The proton relaxation times of autopsy samples of arterial intima-media were measured with an NMR spectrometer and results correlated to the microscopically estimated lipid content of the vascular wall. The normal arterial intima-media contained two T1 relaxation components. The short T1 component (T1s) was 90 +/- 13 ms and its relative weight was 11%. The long T1 component (T1l) was 523 +/- 89 ms and relative weight 88%, respectively. The average T2 was 99 +/- 18 ms. In diseased vessels, a positive correlation was found between the lipid content of the vessel wall and the relaxation rate of the fast component. T1s of the intima-media was significantly shorter (P less than .01) in severe atheromatosis compared with vessels without fat deposition. The results suggest that atheromatous lesions should be best highlighted in spin-echo images by using short TR and TE to suppress the influence of T1l and to avoid (noncontrast contributing) T2 decay of the signal intensity.
用核磁共振光谱仪测量动脉内膜 - 中膜尸检样本的质子弛豫时间，并将结果与血管壁微观估计的脂质含量相关联。正常动脉内膜 - 中膜包含两个T1弛豫成分。短T1成分（T1s）为90±13毫秒，其相对权重为11%。长T1成分（T1l）分别为523±89毫秒和相对权重88%。平均T2为99±18毫秒。在病变血管中，发现血管壁脂质含量与快速成分的弛豫率之间存在正相关。与无脂肪沉积的血管相比，严重动脉粥样硬化时内膜 - 中膜的T1s显著缩短（P小于0.01）。结果表明，在自旋回波图像中，通过使用短TR和TE抑制T1l的影响并避免信号强度的（无对比作用的）T2衰减，动脉粥样硬化病变应能得到最佳突出显示。
