Stone H B, Harding R P
Int J Radiat Oncol Biol Phys. 1986 May;12(5):823-7. doi: 10.1016/0360-3016(86)90042-8.
Skin contraction and leg contracture resulted from immersion of mice legs in a water bath at temperatures of 42.5 degrees to 43.7 degrees C for 45 to 90 minutes. The maximum contracture was observed between 5 and 15 days after treatment, but little damage remained after about 30 days. After healing of the early tissue damage, there was no progression of residual damage in skin up to 490 days after treatment. In contrast, radiation-induced contracture develops rapidly after 14 days, and may continue to progress for 100 days or more. In the present studies, leg contracture could be attributed primarily to injury in the skin, because skinning the legs before measuring eliminated most of the contracture. Temperature differences between subcutaneous tissue and deep muscle were not consistently observed or statistically significant, and probably made little or no contribution to the difference in thermal response of these tissues.
将小鼠腿部浸入温度为42.5摄氏度至43.7摄氏度的水浴中45至90分钟会导致皮肤收缩和腿部挛缩。在治疗后5至15天观察到最大挛缩，但约30天后几乎没有残留损伤。早期组织损伤愈合后，治疗后长达490天皮肤中残留损伤没有进展。相比之下，辐射诱导的挛缩在14天后迅速发展，并且可能持续进展100天或更长时间。在本研究中，腿部挛缩主要可归因于皮肤损伤，因为在测量前剥去腿部皮肤消除了大部分挛缩。皮下组织和深部肌肉之间的温度差异未始终观察到或无统计学意义，并且可能对这些组织的热反应差异几乎没有或没有贡献。
