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使用正丁基氰基丙烯酸酯进行血管内动脉瘤囊栓塞术治疗主髂段破裂动脉瘤

Endovascular Aneurysm Sac Embolization for Treatment of Ruptured Aneurysms in the Aortoiliac Segment Using N-Butyl-Cyanoacrylate.

作者信息

Mostafa Karim, Schierenbeck Marie, Trentmann Jens, Gottschalk Hannes, Andersson Julian, Pfarr Julian, Sieren Malte, Jansen Olav, Schäfer Philipp J

机构信息

Department for Radiology and Neuroradiology, University Hospital Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany.

Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, 23569 Lübeck, Germany.

出版信息

Life (Basel). 2023 Mar 31;13(4):919. doi: 10.3390/life13040919.

Abstract

Aneurysmal rupture in the aortoiliac segment is a severe, life-threatening condition. Nowadays, in addition to surgical treatment, the implantation of a covered stent graft constitutes a feasible, minimally invasive treatment option. A novel approach is the add-on of transarterial aneurysm sac embolization with N-butyl-cyanoacrylate (NBCA). Here, we report our experience of performing this add-on embolization procedure after endovascular aneurysm repair for complex ruptured aneurysms of the aortoiliac segment. We describe six patients (mean age of 75.2 years; all male) with ruptured aneurysms in the visceral aortic and aortoiliac segment in whom a high-volume transarterial aneurysm sac embolization was performed as an add-on therapy to the implantation of an aortic prosthesis. The aim of this add-on intervention was to achieve the definite embolization of the aneurysmal rupture site and to ensure the best possible aneurysmal sealing. We report the feasibility, technical success, and considerations of using NBCA as well as clinical and follow-up imaging results, given their availability. Technical success was achieved in all cases. Clinical success was achieved in four cases. No periprocedural complications or reinterventions were reported. The mean full procedure time was 107.8 min. The mean radiation dose was 12,966.1 cGy/cm. A mean amount of 10.7 mL of NBCA mixed with lipiodol in a 1:3 to 1:5 ratio was used for all patients. Available follow-up imaging up to 36 months after the procedure showed no aneurysm progression or endoleaks. In two patients, the NBCA cast had almost fully dissolved over the course of follow-up. Our study underscores the notion that aneurysm sac embolization using high volumes of NBCA with ethiodized oil as an embolic agent is a feasible and add-on treatment option for optimizing the exclusion of the aneurysm from patients with ruptured aneurysms in the aortoiliac segment.

摘要

腹主动脉髂动脉段动脉瘤破裂是一种严重的、危及生命的疾病。如今,除了手术治疗外,植入覆膜支架移植物是一种可行的微创治疗选择。一种新的方法是附加使用N-丁基-氰基丙烯酸酯(NBCA)进行经动脉动脉瘤囊栓塞。在此,我们报告我们在血管内动脉瘤修复术后对复杂的腹主动脉髂动脉段破裂动脉瘤进行这种附加栓塞术的经验。我们描述了6例(平均年龄75.2岁;均为男性)腹主动脉内脏段和腹主动脉髂动脉段动脉瘤破裂的患者,他们接受了大容量经动脉动脉瘤囊栓塞术,作为主动脉假体植入的附加治疗。这种附加干预的目的是实现动脉瘤破裂部位的确定性栓塞,并确保尽可能好的动脉瘤封闭。鉴于NBCA的可用性,我们报告了其可行性、技术成功率、使用时的注意事项以及临床和随访影像学结果。所有病例均取得技术成功。4例取得临床成功。未报告围手术期并发症或再次干预。平均整个手术时间为107.8分钟。平均辐射剂量为12,966.1 cGy/cm。所有患者均使用平均10.7 mL按1:3至1:5比例与碘油混合的NBCA。术后长达36个月的可用随访影像学检查显示无动脉瘤进展或内漏。在2例患者中,NBCA铸型在随访过程中几乎完全溶解。我们的研究强调了这样一种观念,即使用大量NBCA与碘化油作为栓塞剂进行动脉瘤囊栓塞是一种可行的附加治疗选择,可优化对腹主动脉髂动脉段破裂动脉瘤患者动脉瘤的排除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9213/10145858/2c82ed205467/life-13-00919-g003.jpg

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