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稳定性心绞痛和冠状动脉慢血流患者的长期死亡率预测因素。

Predictors of Long-Term Mortality in Patients with Stable Angina Pectoris and Coronary Slow Flow.

机构信息

Department of Cardiology, Dr. Siyami Ersek Training and Research Hospital, University of Health Sciences, Istanbul 34668, Turkey.

Department of Cardiology, Faculty of Medicine, Medeniyet University, Istanbul 34722, Turkey.

出版信息

Medicina (Kaunas). 2023 Apr 14;59(4):763. doi: 10.3390/medicina59040763.

Abstract

: Coronary slow flow (CSF) is an angiographic phenomenon characterized by the slow progression of an injected contrast agent during diagnostic coronary angiography in the absence of significant stenosis. Although CSF is a common angiographic finding, the long-term outcomes and mortality rates are still unknown. This study aimed to investigate the underlying causes of mortality over a 10-year period in patients diagnosed with stable angina pectoris (SAP) and CSF. : This study included patients with SAP who underwent coronary angiography from 1 January 2012 to 31 December 2012. All patients displayed CSF despite having angiographically normal coronary arteries. Hypertension (HT), diabetes mellitus (DM), hyperlipidaemia, medication compliance, comorbidities, and laboratory data were recorded at the time of angiography. Thrombolysis in myocardial infarction (TIMI) frame count (TFC) was calculated for each patient. The cardiovascular (CV) and non-CV causes of long-term mortality were assessed. A total of 137 patients with CSF (93 males; mean age: 52.2 ± 9.36 years) were included in this study. Twenty-one patients (15.3%) died within 10 years of follow-up. Nine (7.2%) and 12 (9.4%) patients died of non-CV and CV causes, respectively. Total mortality in patients with CSF was associated with age, HT, discontinuation of medications, and high-density lipoprotein cholesterol (HDL-C) levels. The mean TFC was associated with CV mortality. Patients with CSF exhibited a notable increase in cardiovascular-related and overall mortality rates after 10 years of follow-up. HT, discontinuation of medications, HDL-C levels, and mean TFC were associated with mortality in patients with CSF.

摘要

: 冠状动脉慢血流(CSF)是一种血管造影现象,其特征为在诊断性冠状动脉造影中,即使不存在明显狭窄,造影剂的注入也进展缓慢。尽管 CSF 是一种常见的血管造影发现,但长期预后和死亡率仍不清楚。本研究旨在探讨在 10 年内诊断为稳定型心绞痛(SAP)和 CSF 的患者的死亡原因。: 本研究纳入了 2012 年 1 月 1 日至 2012 年 12 月 31 日期间接受冠状动脉造影的 SAP 患者。所有患者的冠状动脉造影均正常,但均存在 CSF。记录了高血压(HT)、糖尿病(DM)、高脂血症、药物依从性、合并症和实验室数据。计算每位患者的心肌梗死溶栓治疗(TIMI)帧数(TFC)。评估了长期死亡率的心血管(CV)和非 CV 原因。共有 137 名 CSF 患者(93 名男性;平均年龄:52.2 ± 9.36 岁)纳入本研究。21 名患者(15.3%)在随访 10 年内死亡。9 名(7.2%)和 12 名(9.4%)患者分别死于非 CV 和 CV 原因。CSF 患者的总死亡率与年龄、HT、药物停药和高密度脂蛋白胆固醇(HDL-C)水平相关。平均 TFC 与 CV 死亡率相关。CSF 患者在随访 10 年后,心血管相关和总体死亡率显著增加。HT、药物停药、HDL-C 水平和平均 TFC 与 CSF 患者的死亡率相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a22e/10144203/d530e4a2df5e/medicina-59-00763-g001.jpg

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