Délicat-Loembet Lucrèce M, Baraïka Mohamed Ag, Bougoudogo Flabou, Diallo Dapa A
Department of Biology, Faculty of Sciences, University of Sciences and Techniques of Masuku (USTM), Franceville BP 901, Gabon.
NGO Sickle Cell Disease Organization of Gabon, Moanda 27/28, Gabon.
Microorganisms. 2023 Mar 28;11(4):859. doi: 10.3390/microorganisms11040859.
The high frequency of bacterial infections represents a major threat to public health. In developing countries, they are still responsible for significant morbidity and mortality in pediatric populations with sickle cell disease, particularly in children under 5 years of age. Indeed, they have an increased susceptibility to bacterial infections due to their immune deficiency. This susceptibility is even greater for pneumococcal and salmonella infections. In addition, the underdevelopment of some countries and socio-economic factors increases this condition. This review examines the common and specific factors leading to infections in people with sickle cell disease in different types of developed and undeveloped countries. The threat of bacterial infections, particularly those caused by S. pneumoniae and Salmonella, is of increasing concern due to the rise in bacterial resistance to antibiotics. In light of this disturbing data, new strategies to control and prevent these infections are needed. Solutions could be systematic penicillin therapy, vaccinations, and probabilistic antibiotic therapy protocols.
细菌感染的高发生率对公众健康构成了重大威胁。在发展中国家，它们仍是导致镰状细胞病儿童群体出现显著发病和死亡的主要原因，尤其是5岁以下的儿童。事实上，由于免疫缺陷，他们对细菌感染的易感性增加。对于肺炎球菌和沙门氏菌感染，这种易感性甚至更高。此外，一些国家的不发达以及社会经济因素加剧了这种情况。本综述探讨了在不同类型的发达国家和不发达国家中，导致镰状细胞病患者感染的常见和特定因素。由于细菌对抗生素的耐药性增加，细菌感染的威胁，尤其是由肺炎链球菌和沙门氏菌引起的感染，日益受到关注。鉴于这些令人不安的数据，需要新的策略来控制和预防这些感染。解决办法可能包括系统性青霉素治疗、疫苗接种和概率性抗生素治疗方案。
