Aldriwesh Marwh G, Al-Mutairi Abrar M, Alharbi Azzah S, Aljohani Hassan Y, Alzahrani Nabeel A, Ajina Reham, Alanazi Abdullah M
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
King Abdullah International Medical Research Center, Riyadh 11481, Saudi Arabia.
Microorganisms. 2023 Apr 3;11(4):939. doi: 10.3390/microorganisms11040939.
Evidence from the literature suggests an association between the microbiome and asthma development. Here, we aimed to identify the current evidence for the association between asthma and the upper airway, lower airway and/or the gut microbiome. An electronic systemic search of PubMed, EBSCO, Science Direct and Web of Science was conducted until February 2022 to identify the eligible studies. The Newcastle-Ottawa Scale and the Systematic Review Centre for Laboratory Animal Experimentation risk of the bias tools were used to assess quality of included studies. Twenty-five studies met the inclusion criteria. Proteobacteria and Firmicutes were identified as being significantly higher in the asthmatic children compared with the healthy controls. The high relative abundance of , and in the microbiome of the upper airway in early infancy was associated with a higher risk of asthma development later in life. The gut microbiome analyses indicated that a high relative abundance of in early childhood might be associated with asthma development later in life. The findings reported here serve as potential microbiome signatures associated with the increased risk of asthma development. There is a need for large longitudinal studies to further identify high-risk infants, which will help in design strategies and prevention mechanisms to avoid asthma early in life.
文献证据表明微生物群与哮喘发展之间存在关联。在此，我们旨在确定哮喘与上呼吸道、下呼吸道和/或肠道微生物群之间关联的现有证据。截至2022年2月，我们对PubMed、EBSCO、科学Direct和科学网进行了电子系统检索，以确定符合条件的研究。使用纽卡斯尔-渥太华量表和实验室动物实验系统评价中心的偏倚风险工具来评估纳入研究的质量。25项研究符合纳入标准。与健康对照相比，变形菌门和厚壁菌门在哮喘儿童中显著更高。婴儿早期上呼吸道微生物群中 、 和 的高相对丰度与生命后期哮喘发展的较高风险相关。肠道微生物群分析表明，儿童早期 的高相对丰度可能与生命后期哮喘发展有关。此处报告的研究结果可作为与哮喘发展风险增加相关的潜在微生物群特征。需要进行大型纵向研究以进一步识别高危婴儿，这将有助于设计策略和预防机制，以在生命早期避免哮喘。
