Faculty of General Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Faculty of General Medicine, Ovidius University, 900470 Constanta, Romania.
Nutrients. 2023 Jul 24;15(14):3278. doi: 10.3390/nu15143278.
Considered to be of greater complexity than the human genome itself, the microbiome, the structure of the body made up of trillions of bacteria, viruses, and fungi, has proven to play a crucial role in the context of the development of pathological processes in the body, starting from various infections, autoimmune diseases, atopies, and culminating in its involvement in the development of some forms of cancer, a diagnosis that is considered the most disabling for the patient from a psychological point of view. Therefore, being a cornerstone in the understanding and optimal treatment of a multitude of ailments, the body's microbiome has become an intensively studied subject in the scientific literature of the last decade. This review aims to bring the microbiome-asthma correlation up to date by classifying asthmatic patterns, emphasizing the development patterns of the microbiome starting from the perinatal period and the impact of pulmonary dysbiosis on asthmatic symptoms in children. Likewise, the effects of intestinal dysbiosis reflected at the level of homeostasis of the internal environment through the intestine-lung/vital organs axis, the circumstances in which it occurs, but also the main methods of studying bacterial variability used for diagnostic purposes and in research should not be omitted. In conclusion, we draw current and future therapeutic lines worthy of consideration both in obtaining and maintaining remission, as well as in delaying the development of primary acute episodes and preventing future relapses.
被认为比人类基因组本身更为复杂的微生物组，即由数万亿细菌、病毒和真菌组成的身体结构，已被证明在身体病理过程的发展中起着至关重要的作用，从各种感染、自身免疫性疾病、过敏症开始，最终涉及到某些形式的癌症的发展，从心理角度来看，这种诊断被认为对患者最具致残性。因此，作为理解和优化治疗多种疾病的基石，人体微生物组已成为过去十年科学文献中研究的热点。本综述旨在通过分类哮喘模式，强调从围产期开始的微生物组的发展模式，以及肺部微生物失调对儿童哮喘症状的影响，使微生物组-哮喘相关性保持最新。同样，通过肠-肺/重要器官轴在内部环境稳态水平上反映的肠道微生物失调，以及它发生的情况，也不应忽略用于诊断目的和研究的细菌变异性的主要研究方法。总之，我们得出了当前和未来的治疗方案，这些方案不仅值得在获得和维持缓解方面考虑，而且值得在延缓急性发作的发展和预防未来复发方面考虑。
