Galeana-Cadena David, Gómez-García Itzel Alejandra, Lopez-Salinas Karen Gabriel, Irineo-Moreno Valeria, Jiménez-Juárez Fabiola, Tapia-García Alan Rodrigo, Boyzo-Cortes Carlos Alberto, Matías-Martínez Melvin Barish, Jiménez-Alvarez Luis, Zúñiga Joaquín, Camarena Angel
Laboratorio de Inmunobiología y Genética, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City, Mexico.
Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.
Front Microbiol. 2023 Dec 11;14:1295215. doi: 10.3389/fmicb.2023.1295215. eCollection 2023.
The role of the microbiome in asthma is highlighted, considering its influence on immune responses and its connection to alterations in asthmatic patients. In this context, we review the variables influencing asthma phenotypes from a microbiome perspective and provide insights into the microbiome's role in asthma pathogenesis. Previous cohort studies in patients with asthma have shown that the presence of genera such as , and in the gut microbiome has been associated with protection against the disease. While, the presence of other genera such as , and in the respiratory microbiome has been implicated in asthma pathogenesis, indicating a potential link between microbial dysbiosis and the development of asthma. Furthermore, respiratory infections have been demonstrated to impact the composition of the upper respiratory tract microbiota, increasing susceptibility to bacterial diseases and potentially triggering asthma exacerbations. By understanding the interplay between the microbiome and asthma, valuable insights into disease mechanisms can be gained, potentially leading to the development of novel therapeutic approaches.
考虑到微生物群对免疫反应的影响及其与哮喘患者体内变化的联系，其在哮喘中的作用备受关注。在此背景下，我们从微生物群的角度回顾影响哮喘表型的变量，并深入探讨微生物群在哮喘发病机制中的作用。先前针对哮喘患者的队列研究表明，肠道微生物群中某些属（如 、 和 ）的存在与预防该疾病有关。而呼吸道微生物群中其他属（如 、 和 ）的存在则与哮喘发病机制有关，这表明微生物群落失调与哮喘的发展之间存在潜在联系。此外，呼吸道感染已被证明会影响上呼吸道微生物群的组成，增加对细菌性疾病的易感性，并可能引发哮喘发作。通过了解微生物群与哮喘之间的相互作用，可以获得有关疾病机制的宝贵见解，这可能会促使新型治疗方法的开发。
