Asai Nobuhiro, Shibata Yuichi, Nakamura Akiko, Suematsu Hiroyuki, Yamada Atsuko, Ohno Tomoko, Sakanashi Daisuke, Kawamoto Yuzuka, Miyazaki Narimi, Koita Isao, Kato Hideo, Hagihara Mao, Ohta Hirotoshi, Mikamo Hiroshige
Department of Clinical Infectious Diseases, Aichi Medical University Hospital, Nagakute 480-1195, Japan.
Department of Infection Control and Prevention, Aichi Medical University Hospital, Nagakute 480-1195, Japan.
Microorganisms. 2023 Apr 20;11(4):1076. doi: 10.3390/microorganisms11041076.
Fungemia is a fatal systemic infection that can occur in immunocompromised patients. Despite that, antifungal stewardship is spreading widely, but the mortality rate is extremely high, showing 40-60%. is a newly morphologically detected pathogen, first described in 1994, followed by isolation in humans in 2008. It has been misrecognized as . Recently, fever attributable to fungemia cases has been reported, and the etiology and clinical features are still unknown. Here, we present three successfully treated fungemia cases by echinocandin. In total, 11 cases were reviewed, including ours. Six of the eleven cases (55%) had external devices. All cases had some immunocompromised conditions or underlying diseases, such as diabetes mellitus, lung cancer, etc. Six patients survived, and the remaining five died. Seven patients who had received echinocandin initially survived. Risk factors for fungemia overlap with those of candidemia. Even though there is no breakpoint for , echinocandin can be a helpful treatment regimen for fungemia.
真菌血症是一种可发生在免疫功能低下患者中的致命性全身感染。尽管如此，抗真菌管理正在广泛开展，但死亡率极高，达40% - 60%。（此处原文缺失病原体名称）是一种新发现的形态学病原体，于1994年首次描述，2008年在人类中分离出来。它曾被误认作（此处原文缺失相关内容）。最近，已有因（此处原文缺失病原体名称）真菌血症病例导致发热的报道，但其病因和临床特征仍不清楚。在此，我们报告3例通过棘白菌素成功治疗的（此处原文缺失病原体名称）真菌血症病例。总共回顾了11例病例，包括我们的病例。11例病例中有6例（55%）有外部装置。所有病例都有一些免疫功能低下状况或基础疾病，如糖尿病、肺癌等。6例患者存活，其余5例死亡。最初接受棘白菌素治疗的7例患者存活。（此处原文缺失病原体名称）真菌血症的危险因素与念珠菌血症的危险因素重叠。尽管（此处原文缺失病原体名称）没有折点，但棘白菌素可能是治疗（此处原文缺失病原体名称）真菌血症的一种有效治疗方案。
