Department of Family Medicine, Taipei City Hospital, Heping Fuyou Branch, Taipei 100, Taiwan.
Department of Family Medicine, Cardinal Tien Hospital, New Taipei 231, Taiwan.
Molecules. 2023 Apr 12;28(8):3386. doi: 10.3390/molecules28083386.
The Lion's mane mushroom (Hericium erinaceus, HE) is a traditional medical mushroom with high nutritional and economic value. HE possesses anticancer, antimicrobial, antioxidant, immunomodulating, neurotrophic, and neuroprotective activities. The present study evaluated the protection and antioxidative activities of micronized mycelium of HE (HEM) in mice treated with 1-methyl-4-phenylpyridinium (MPTP). HEM was cultivated via solid-state fermentation and micronized using cell wall-breaking technology to increase its bioavailability when ingested. Erinacine A, the bioactive compound in the HEM, played a pivotal role in antioxidant defense. We found that micronized HEM could recover the dopamine level in the mice striatum in a dose-dependent manner that had been greatly reduced during MPTP treatment. Moreover, the malondialdehyde (MDA) and carbonyl levels were reduced in the livers and brains of the MPTP + HEM-treated groups compared with the MPTP group. Additionally, antioxidant enzyme activities, including catalase, superoxide dismutase (SOD), glucose-6-phosphate dehydrogenase (G6PDH), and glutathione reductase (GRd), were elevated after the administration of HEM in MPTP-treated mice in a dose-dependent manner. Taken together, our data indicate that HEM cultivated via solid-state fermentation and processed with cell wall-breaking technology showed an excellent antioxidant efficacy.
狮子鬃蘑菇（Hericium erinaceus，HE）是一种具有高营养价值和经济价值的传统药用蘑菇。HE 具有抗癌、抗菌、抗氧化、免疫调节、神经营养和神经保护作用。本研究评估了经固态发酵培养并用细胞壁破碎技术微粉化的 HE（HEM）在 1-甲基-4-苯基吡啶（MPTP）处理的小鼠中的保护和抗氧化活性。HEM 通过固态发酵培养并用细胞壁破碎技术微粉化，以增加其摄入时的生物利用度。HEM 中的生物活性化合物——角鲨烯 A 在抗氧化防御中发挥着关键作用。我们发现，微粉化的 HEM 可以剂量依赖性地恢复 MPTP 处理后大大降低的小鼠纹状体中的多巴胺水平。此外，与 MPTP 组相比，MPTP+HEM 治疗组的肝脏和大脑中的丙二醛（MDA）和羰基水平降低。此外，在给予 HEM 后，MPTP 处理的小鼠中的抗氧化酶活性，包括过氧化氢酶、超氧化物歧化酶（SOD）、葡萄糖-6-磷酸脱氢酶（G6PDH）和谷胱甘肽还原酶（GRd），均呈剂量依赖性升高。综上所述，我们的数据表明，经固态发酵培养并用细胞壁破碎技术处理的 HEM 表现出优异的抗氧化功效。
