Velhal Kamini, Barage Sagar, Roy Arpita, Lakkakula Jaya, Yamgar Ramesh, Alqahtani Mohammed S, Yadav Krishna Kumar, Ahn Yongtae, Jeon Byong-Hun
Amity Institute of Biotechnology, Amity University, Mumbai-Pune Expressway, Bhatan, Panvel, Mumbai 410206, India.
Centre for Computational Biology and Translational Research, Amity Institute of Biotechnology, Amity University, Mumbai-Pune Expressway, Bhatan, Panvel, Mumbai 410206, India.
Polymers (Basel). 2022 Aug 3;14(15):3162. doi: 10.3390/polym14153162.
This review presented the unique characteristics of different types of cyclodextrin polymers by non-covalent host-guest interactions to synthesize an inclusion complex. Various cancers are treated with different types of modified cyclodextrins, along with the anticancer drug paclitaxel. PTX acts as a mitotic inhibitor, but due to its low dissolution and permeability in aqueous solutions, it causes considerable challenges for drug delivery system (DDS) designs. To enhance the solubility, it is reformulated with derivatives of cyclodextrins using freeze-drying and co-solvent lyophilization methods. The present supramolecular assemblies involve cyclodextrin as a key mediator, which is encapsulated with paclitaxel and their controlled release at the targeted area is highlighted using different DDS. In addition, the application of cyclodextrins in cancer treatment, which reduces the off-target effects, is briefly demonstrated using various types of cancer cell lines. A new nano-formulation of PTX is used to improve the antitumor activity compared to normal PTX DDS in lungs and breast cancer is well defined in the present review.
本综述介绍了通过非共价主客体相互作用合成包合物的不同类型环糊精聚合物的独特特性。不同类型的改性环糊精与抗癌药物紫杉醇一起用于治疗各种癌症。紫杉醇作为一种有丝分裂抑制剂，但由于其在水溶液中的低溶解性和渗透性，给药物递送系统（DDS）设计带来了相当大的挑战。为了提高溶解度，使用冷冻干燥和共溶剂冻干法将其与环糊精衍生物重新配制。目前的超分子组装体以环糊精作为关键介质，环糊精与紫杉醇包封，并使用不同的药物递送系统突出其在靶向区域的控释。此外，利用各种癌细胞系简要展示了环糊精在癌症治疗中的应用，其可减少脱靶效应。与正常的紫杉醇药物递送系统相比，一种新的紫杉醇纳米制剂用于提高抗肿瘤活性，本综述对其在肺癌和乳腺癌中的应用进行了明确阐述。
