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基于环糊精的超分子水凝胶在组织工程与再生医学中的应用

Cyclodextrin-Based Supramolecular Hydrogels in Tissue Engineering and Regenerative Medicine.

作者信息

Lin Jiamin, Chen Yuanyuan, Wang Xuemei

机构信息

State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

出版信息

Molecules. 2025 Jul 31;30(15):3225. doi: 10.3390/molecules30153225.

DOI:10.3390/molecules30153225
PMID:40807400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12348549/
Abstract

Cyclodextrins (CDs), cyclic oligosaccharides formed by α-1,4-glycosidic-bonded D-glucopyranose units, feature unique hydrophobic cavities and hydrophilic exteriors that enable molecular encapsulation via host-guest interactions. CDs form supramolecular host-guest complexes with diverse molecular entities, establishing their fundamental role in supramolecular chemistry. This review examines fabrication strategies for CD-based supramolecular hydrogels and their applications in tissue engineering and regenerative medicine, with focused analysis on wound healing, corneal regeneration, and bone repair. We critically analyze CD-guest molecular interaction mechanisms and innovative therapeutic implementations, highlighting the significant potential of CD hydrogels for tissue regeneration while addressing clinical translation challenges and future directions.

摘要

环糊精（CDs）是由α-1,4-糖苷键连接的D-吡喃葡萄糖单元形成的环状寡糖，具有独特的疏水内腔和亲水外部，能够通过主客体相互作用实现分子包封。CDs与多种分子实体形成超分子主客体复合物，确立了它们在超分子化学中的基本作用。本综述探讨了基于CD的超分子水凝胶的制备策略及其在组织工程和再生医学中的应用，重点分析了伤口愈合、角膜再生和骨修复方面的应用。我们批判性地分析了CD-客体分子相互作用机制和创新治疗方法，强调了CD水凝胶在组织再生方面的巨大潜力，同时探讨了临床转化挑战和未来发展方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/e32057a688f9/molecules-30-03225-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/26a040151fdc/molecules-30-03225-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/0785c45e0db7/molecules-30-03225-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/4b6692218949/molecules-30-03225-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/18d7e2df0069/molecules-30-03225-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/0b6ce0967a0d/molecules-30-03225-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/e32057a688f9/molecules-30-03225-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/26a040151fdc/molecules-30-03225-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/0785c45e0db7/molecules-30-03225-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/4b6692218949/molecules-30-03225-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/18d7e2df0069/molecules-30-03225-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/0b6ce0967a0d/molecules-30-03225-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8bb/12348549/e32057a688f9/molecules-30-03225-g005.jpg

相似文献

[1]
Cyclodextrin-Based Supramolecular Hydrogels in Tissue Engineering and Regenerative Medicine.

Molecules. 2025-7-31

[2]
Tailored polymeric hydrogels for regenerative medicine and drug delivery: From material design to clinical applications.

Int J Pharm. 2025-8-20

[3]
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Acta Biomater. 2025-7-16

[4]
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Acta Biomater. 2025-7-1

[5]
Supramolecular polymeric materials via cyclodextrin-guest interactions.

Acc Chem Res. 2014-6-9

[6]
Advances in β-Cyclodextrin-Driven Self-Healing Materials: Molecular Design and Multifunctional Applications.

Adv Mater. 2025-8-16

[7]
Recent Advances in Cyclodextrin-Based Nanoscale Drug Delivery Systems.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024

[8]
Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine.

Macromol Biosci. 2018-10-8

[9]
Biomaterial-Based Nucleic Acid Delivery Systems for In Situ Tissue Engineering and Regenerative Medicine.

Int J Mol Sci. 2025-7-30

[10]
An introduction to injectable hydrogels.

J Mater Chem B. 2024-6-12

本文引用的文献

[1]
Fabrication of Janus-adhesion Multifunctional Hydrogel Based on β-cyclodextrin for Wound Dressing.

Adv Healthc Mater. 2025-6

[2]
Cyclodextrin-based self-assembling hydrogel for Photothermal-controlled nitric oxide release in stage-specific treatment of MRSA-induced arthritis.

Carbohydr Polym. 2025-7-1

[3]
Cyclodextrins as multifunctional tools for advanced biomaterials in tissue repair and regeneration.

Bioact Mater. 2025-3-27

[4]
An injectable multifunctional nanocomposite hydrogel promotes vascularized bone regeneration by regulating macrophages.

J Nanobiotechnology. 2025-4-7

[5]
Topologically-crosslinked hydrogels based on γ-cyclodextrins.

Commun Chem. 2025-4-2

[6]
Photocurable Dual-Network Hydrogels Based on Natural Polymers for Sutureless Repair of Large Corneal Defects.

Small. 2025-5

[7]
Novel Biomimetic Collagen-Based Corneal Repair Material Achieved via a "Killing Two Birds with One Stone" Strategy Using Carboxymethyl-β-Cyclodextrin.

ACS Biomater Sci Eng. 2025-4-14

[8]
Bioactive hydrogel formulations for regeneration of pathological bone defects.

J Control Release. 2025-4-10

[9]
Herbal micelles-loaded ROS-responsive hydrogel with immunomodulation and microenvironment reconstruction for diabetic wound healing.

Biomaterials. 2025-6

[10]
Nanoemulsion-based pseudopolyrotaxane hydrogel for enhanced corneal bioavailability and treatment of corneal inflammation.

J Control Release. 2025-3-10

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