Lin Jiamin, Chen Yuanyuan, Wang Xuemei
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Molecules. 2025 Jul 31;30(15):3225. doi: 10.3390/molecules30153225.
Cyclodextrins (CDs), cyclic oligosaccharides formed by α-1,4-glycosidic-bonded D-glucopyranose units, feature unique hydrophobic cavities and hydrophilic exteriors that enable molecular encapsulation via host-guest interactions. CDs form supramolecular host-guest complexes with diverse molecular entities, establishing their fundamental role in supramolecular chemistry. This review examines fabrication strategies for CD-based supramolecular hydrogels and their applications in tissue engineering and regenerative medicine, with focused analysis on wound healing, corneal regeneration, and bone repair. We critically analyze CD-guest molecular interaction mechanisms and innovative therapeutic implementations, highlighting the significant potential of CD hydrogels for tissue regeneration while addressing clinical translation challenges and future directions.
环糊精（CDs）是由α-1,4-糖苷键连接的D-吡喃葡萄糖单元形成的环状寡糖，具有独特的疏水内腔和亲水外部，能够通过主客体相互作用实现分子包封。CDs与多种分子实体形成超分子主客体复合物，确立了它们在超分子化学中的基本作用。本综述探讨了基于CD的超分子水凝胶的制备策略及其在组织工程和再生医学中的应用，重点分析了伤口愈合、角膜再生和骨修复方面的应用。我们批判性地分析了CD-客体分子相互作用机制和创新治疗方法，强调了CD水凝胶在组织再生方面的巨大潜力，同时探讨了临床转化挑战和未来发展方向。
