基于环糊精的超分子水凝胶在组织工程与再生医学中的应用
Cyclodextrin-Based Supramolecular Hydrogels in Tissue Engineering and Regenerative Medicine.
作者信息
Lin Jiamin, Chen Yuanyuan, Wang Xuemei
机构信息
State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
出版信息
Molecules. 2025 Jul 31;30(15):3225. doi: 10.3390/molecules30153225.
Cyclodextrins (CDs), cyclic oligosaccharides formed by α-1,4-glycosidic-bonded D-glucopyranose units, feature unique hydrophobic cavities and hydrophilic exteriors that enable molecular encapsulation via host-guest interactions. CDs form supramolecular host-guest complexes with diverse molecular entities, establishing their fundamental role in supramolecular chemistry. This review examines fabrication strategies for CD-based supramolecular hydrogels and their applications in tissue engineering and regenerative medicine, with focused analysis on wound healing, corneal regeneration, and bone repair. We critically analyze CD-guest molecular interaction mechanisms and innovative therapeutic implementations, highlighting the significant potential of CD hydrogels for tissue regeneration while addressing clinical translation challenges and future directions.
环糊精（CDs）是由α-1,4-糖苷键连接的D-吡喃葡萄糖单元形成的环状寡糖，具有独特的疏水内腔和亲水外部，能够通过主客体相互作用实现分子包封。CDs与多种分子实体形成超分子主客体复合物，确立了它们在超分子化学中的基本作用。本综述探讨了基于CD的超分子水凝胶的制备策略及其在组织工程和再生医学中的应用，重点分析了伤口愈合、角膜再生和骨修复方面的应用。我们批判性地分析了CD-客体分子相互作用机制和创新治疗方法，强调了CD水凝胶在组织再生方面的巨大潜力，同时探讨了临床转化挑战和未来发展方向。
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