Amity Institute of Biotechnology, Amity University, Sector 125, Noida 201313, UP, India.
Amity Institute of Click Chemistry Research and Studies, Amity University, Sector 125, Noida 201313, UP, India.
Molecules. 2023 Apr 17;28(8):3524. doi: 10.3390/molecules28083524.
The asymmetric reactions of imines continued to attract the attention of the scientific community for decades. However, the stereoselective reactions of -phosphonyl/phosphoryl imines remained less explored as compared to other -substituted imines. The chiral auxiliary-based asymmetric-induction strategy with -phosphonyl imines could effectively generate enantio- and diastereomeric amine, ,-diamine, and other products through various reactions. On the other hand, the asymmetric approach for the generation of chirality through the utilization of optically active ligands, along with metal catalysts, could be successfully implemented on -phosphonyl/phosphoryl imines to access numerous synthetically challenging chiral amine scaffolds. The current review critically summarizes and reveals the literature precedence of more than a decade to highlight the major achievements existing to date that can display a clear picture of advancement as well drawbacks in this area.
手性膦酰/磷酰亚胺的不对称反应：综述
